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N acetyl cysteine with weight reduction
N-acetyl cysteine replenishes glutathione stores and provides antioxidant support while weight reduction interventions decrease metabolic burden and improve insulin sensitivity.
N-acetyl cysteine replenishes glutathione stores and provides antioxidant support while weight reduction interventions decrease metabolic burden and improve insulin sensitivity. Used for Metabolic syndrome with weight management, Non-alcoholic fatty liver disease (NAFLD), Insulin resistance or prediabetes.
At a glance
| Generic name | N acetyl cysteine with weight reduction |
|---|---|
| Sponsor | Ain Shams University |
| Drug class | Antioxidant with lifestyle intervention |
| Target | Glutathione synthesis pathway; indirect metabolic targets via weight reduction |
| Modality | Small molecule |
| Therapeutic area | Metabolic/Endocrinology |
| Phase | Phase 3 |
Mechanism of action
N-acetyl cysteine (NAC) is a precursor to the antioxidant glutathione, which helps reduce oxidative stress and inflammation. Combined with weight reduction strategies, this approach targets metabolic dysfunction by simultaneously improving antioxidant defense and reducing adiposity-related metabolic complications. The combination may address both oxidative stress and insulin resistance in metabolic disorders.
Approved indications
- Metabolic syndrome with weight management
- Non-alcoholic fatty liver disease (NAFLD)
- Insulin resistance or prediabetes
Common side effects
- Nausea
- Gastrointestinal upset
- Headache
- Rash
Key clinical trials
- N-acetyl Cysteine and Patients with Non-alcoholic Fatty Liver Disease (PHASE3)
- Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS) (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- N acetyl cysteine with weight reduction CI brief — competitive landscape report
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- Ain Shams University portfolio CI