{"id":"n-acetyl-cysteine-with-weight-reduction","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"N-acetyl cysteine (NAC) is a precursor to the antioxidant glutathione, which helps reduce oxidative stress and inflammation. Combined with weight reduction strategies, this approach targets metabolic dysfunction by simultaneously improving antioxidant defense and reducing adiposity-related metabolic complications. The combination may address both oxidative stress and insulin resistance in metabolic disorders.","oneSentence":"N-acetyl cysteine replenishes glutathione stores and provides antioxidant support while weight reduction interventions decrease metabolic burden and improve insulin sensitivity.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:22:29.145Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metabolic syndrome with weight management"},{"name":"Non-alcoholic fatty liver disease (NAFLD)"},{"name":"Insulin resistance or prediabetes"}]},"trialDetails":[{"nctId":"NCT05589584","phase":"PHASE3","title":"N-acetyl Cysteine and Patients with Non-alcoholic Fatty Liver Disease","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2022-11-01","conditions":"Simple Steatosis Non Fatty Liver","enrollment":60},{"nctId":"NCT01381354","phase":"PHASE1","title":"Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)","status":"COMPLETED","sponsor":"University of Iowa","startDate":"2010-10","conditions":"Multiple Sclerosis","enrollment":38}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"N acetyl cysteine with weight reduction","genericName":"N acetyl cysteine with weight reduction","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"N-acetyl cysteine replenishes glutathione stores and provides antioxidant support while weight reduction interventions decrease metabolic burden and improve insulin sensitivity. Used for Metabolic syndrome with weight management, Non-alcoholic fatty liver disease (NAFLD), Insulin resistance or prediabetes.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}