Last reviewed 2026-04-22 · How we verify

Mylan generic fentanyl

Fentanyl is a synthetic opioid that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation.

Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. Used for Moderate to severe acute pain, Chronic pain management, Cancer pain.

At a glance

Mechanism of action

Fentanyl acts as an agonist at mu (μ) opioid receptors, which are G-protein coupled receptors distributed throughout the brain and spinal cord. This binding modulates pain perception and produces analgesic and sedative effects. It is approximately 50-100 times more potent than morphine on a weight basis.

Approved indications

• Moderate to severe acute pain
• Chronic pain in opioid-tolerant patients
• Perioperative analgesia and sedation

Common side effects

• Respiratory depression
• Sedation
• Nausea
• Constipation
• Dizziness
• Pruritus

Key clinical trials

• Fentanyl Patch Pharmacokinetics in Healthy Adults (PHASE4)
• Transdermal Patch CVD 2000: The Effect of Heat on Fentanyl Release From Fentanyl TDSs in Healthy Adults (PHASE4)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

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