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Mulberry Leaf Extract
Mulberry leaf extract inhibits alpha-glucosidase enzymes in the small intestine, slowing carbohydrate digestion and reducing postprandial blood glucose levels.
Mulberry leaf extract inhibits alpha-glucosidase enzymes in the small intestine, slowing carbohydrate digestion and reducing postprandial blood glucose levels. Used for Type 2 diabetes mellitus, Postprandial hyperglycemia.
At a glance
| Generic name | Mulberry Leaf Extract |
|---|---|
| Also known as | Mulberry, Morus indica L., Morus alba |
| Sponsor | University of Mississippi Medical Center |
| Drug class | Alpha-glucosidase inhibitor |
| Target | Alpha-glucosidase enzymes (intestinal disaccharidases) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology / Diabetes |
| Phase | FDA-approved |
Mechanism of action
The extract contains iminosugars (particularly 1-deoxynojirimycin) and polyphenols that competitively inhibit intestinal enzymes responsible for breaking down disaccharides and complex carbohydrates. This delays glucose absorption, resulting in lower postprandial glucose spikes and improved glycemic control. The mechanism also involves potential improvements in insulin sensitivity and lipid metabolism.
Approved indications
- Type 2 diabetes mellitus
- Postprandial hyperglycemia
Common side effects
- Gastrointestinal disturbance (bloating, flatulence, diarrhea)
- Abdominal discomfort
Key clinical trials
- Effect of a Reducose®-Based Supplement on Metabolic Health in Subjects With Metabolic Syndrome (NA)
- Effect of Visualization of Functional Milk Efficacy on Perceived Benefits (NA)
- Impact of Reducose® on Glycemic Response and Menopausal Symptoms in Perimenopausal Women (CALM-R) (NA)
- Effects of Milk Probiotics Intervention on Blood Glucose Control Middle-aged and Elderly People With Pre-diabetes (NA)
- Effect of a Dietary Supplement on Hormones Involved in Appetite Regulation in Overweight and Obese Adults (NA)
- A Study to Evaluate a Postbiotic in Supporting Weight Loss and Metabolic Health (NA)
- Effect of Science Research Wellness Ndo1 on Glycaemia in Adults With Pre-diabetes (NA)
- Effects of Milk Powder Intervention on Blood Glucose Control and Fluctuation in Middle-aged and Elderly People With Pre-diabetes (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Mulberry Leaf Extract CI brief — competitive landscape report
- Mulberry Leaf Extract updates RSS · CI watch RSS
- University of Mississippi Medical Center portfolio CI