{"id":"mulberry-leaf-extract","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance (bloating, flatulence, diarrhea)"},{"rate":null,"effect":"Abdominal discomfort"}]},"_chembl":null,"_dailymed":{"setId":"a4a83a79-7914-4ed1-9439-a9da6e86fb94","title":"ST. PAUL BRANDS GLUCOTROJAN (MANGIFERA INDICA LEAF EXTRACT,STEM BANANA EXTRACT,WHITE MULBERRY (MORUS ALBA) LEAF EXTRACT) CAPSULE [ADVANCED PHARMACEUTICAL SERVICES, INC. DBA AFFORDABLE QUALITY PHARMACEUTICALS]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The extract contains iminosugars (particularly 1-deoxynojirimycin) and polyphenols that competitively inhibit intestinal enzymes responsible for breaking down disaccharides and complex carbohydrates. This delays glucose absorption, resulting in lower postprandial glucose spikes and improved glycemic control. The mechanism also involves potential improvements in insulin sensitivity and lipid metabolism.","oneSentence":"Mulberry leaf extract inhibits alpha-glucosidase enzymes in the small intestine, slowing carbohydrate digestion and reducing postprandial blood glucose levels.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T02:02:12.293Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes mellitus"},{"name":"Postprandial hyperglycemia"}]},"trialDetails":[{"nctId":"NCT07451639","phase":"NA","title":"Effect of a Reducose®-Based Supplement on Metabolic Health in Subjects With Metabolic Syndrome","status":"COMPLETED","sponsor":"Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo","startDate":"2023-03-01","conditions":"Weight Management","enrollment":50},{"nctId":"NCT06864364","phase":"NA","title":"Effect of Visualization of Functional Milk Efficacy on Perceived Benefits","status":"COMPLETED","sponsor":"Société des Produits Nestlé (SPN)","startDate":"2025-02-24","conditions":"Healthy, Prediabetes, Asian","enrollment":170},{"nctId":"NCT07333885","phase":"NA","title":"Impact of Reducose® on Glycemic Response and Menopausal Symptoms in Perimenopausal Women (CALM-R)","status":"RECRUITING","sponsor":"Phynova Group Ltd","startDate":"2025-12-12","conditions":"Glycemic Response, Menopause Symptoms","enrollment":120},{"nctId":"NCT06972524","phase":"NA","title":"Effects of Milk Probiotics Intervention on Blood Glucose Control Middle-aged and Elderly People With Pre-diabetes","status":"NOT_YET_RECRUITING","sponsor":"Huilian Zhu","startDate":"2025-12-01","conditions":"Pre-biabetes","enrollment":110},{"nctId":"NCT07240246","phase":"NA","title":"Effect of a Dietary Supplement on Hormones Involved in Appetite Regulation in Overweight and Obese Adults","status":"RECRUITING","sponsor":"FFoQSI - Austrian Competence Centre for Feed and Food Quality, Safety & Innovation","startDate":"2025-10-24","conditions":"GLP-1, Obesity &Amp; Overweight, Dietary Supplement","enrollment":40},{"nctId":"NCT06911073","phase":"NA","title":"A Study to Evaluate a Postbiotic in Supporting Weight Loss and Metabolic Health","status":"RECRUITING","sponsor":"ResBiotic Nutrition, Inc.","startDate":"2025-05-02","conditions":"Obesity and Overweight","enrollment":80},{"nctId":"NCT06897462","phase":"NA","title":"Effect of Science Research Wellness Ndo1 on Glycaemia in Adults With Pre-diabetes","status":"COMPLETED","sponsor":"Wellizen Australia","startDate":"2025-04-01","conditions":"Prediabetes","enrollment":14},{"nctId":"NCT06863766","phase":"NA","title":"Effects of Milk Powder Intervention on Blood Glucose Control and Fluctuation in Middle-aged and Elderly People With Pre-diabetes","status":"NOT_YET_RECRUITING","sponsor":"Huilian Zhu","startDate":"2025-04-10","conditions":"Pre-diabetes","enrollment":110},{"nctId":"NCT04877366","phase":"NA","title":"Evaluate Effects of Sprinkled Format REDUCOSE in a Carbohydrate-rich, Mixed Meal on Post-prandial Glycemia","status":"COMPLETED","sponsor":"Société des Produits Nestlé (SPN)","startDate":"2021-07-21","conditions":"Dietary Supplement","enrollment":30},{"nctId":"NCT06509204","phase":"NA","title":"Real-world Evaluation of JBA GlucoTrojan With Reducose® on Glycemic Response","status":"COMPLETED","sponsor":"Tastermonial Inc","startDate":"2023-04-04","conditions":"Food Habits","enrollment":30},{"nctId":"NCT06496893","phase":"NA","title":"A Study to Assess Effect of Glucocil® on Metabolic Health in Individuals With Prediabetes and Type 2 Diabetes Mellitus.","status":"NOT_YET_RECRUITING","sponsor":"Vedic Lifesciences Pvt. 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Used for Type 2 diabetes mellitus, Postprandial hyperglycemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}