Last reviewed 2026-04-23 · How we verify

MRI contrast-enhancing preparations

MRI contrast-enhancing preparations work by accumulating in target tissues and altering local magnetic properties to improve visualization on magnetic resonance imaging scans.

MRI contrast-enhancing preparations work by accumulating in target tissues and altering local magnetic properties to improve visualization on magnetic resonance imaging scans. Used for Enhancement of MRI imaging in diagnostic procedures.

At a glance

Mechanism of action

These agents are paramagnetic or superparamagnetic compounds that shorten relaxation times of nearby water protons, creating enhanced signal intensity in MRI images. By distributing to specific anatomical regions or pathological tissues, they improve tissue differentiation and lesion detection compared to non-contrast MRI.

Approved indications

• Enhancement of MRI imaging in diagnostic procedures

Common side effects

• Gadolinium retention (with gadolinium-based agents)
• Nephrogenic systemic fibrosis (rare, with gadolinium in renal impairment)
• Hypersensitivity reactions
• Injection site reactions

Key clinical trials

• Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis (PHASE3)
• Proof-of-concept Study for SAR441344 (Frexalimab) in Relapsing Multiple Sclerosis (PHASE2)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• MRI contrast-enhancing preparations CI brief — competitive landscape report
• MRI contrast-enhancing preparations updates RSS · CI watch RSS
• Sanofi portfolio CI