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Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin
Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin is a Anti-tuberculosis agent combination Small molecule drug developed by Global Alliance for TB Drug Development. It is currently in Phase 3 development for Tuberculosis (drug-susceptible and multidrug-resistant forms). Also known as: Avelox, Avelon, Avalox, Myambutol.
This is a fixed-dose combination of five anti-tuberculosis agents that work through multiple mechanisms to inhibit bacterial cell wall synthesis, protein synthesis, and DNA replication in Mycobacterium tuberculosis.
This is a fixed-dose combination of five anti-tuberculosis agents that work through multiple mechanisms to inhibit bacterial cell wall synthesis, protein synthesis, and DNA replication in Mycobacterium tuberculosis. Used for Tuberculosis (drug-susceptible and multidrug-resistant forms).
At a glance
| Generic name | Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin |
|---|---|
| Also known as | Avelox, Avelon, Avalox, Myambutol, Nydrazid |
| Sponsor | Global Alliance for TB Drug Development |
| Drug class | Anti-tuberculosis agent combination |
| Target | Multiple: DNA gyrase (moxifloxacin), RNA polymerase (rifampicin), mycolic acid synthesis (isoniazid, pyrazinamide), arabinosyl transferase (ethambutol) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Moxifloxacin is a fluoroquinolone that inhibits bacterial DNA gyrase; Rifampicin inhibits bacterial RNA polymerase; Isoniazid and Pyrazinamide inhibit mycobacterial cell wall synthesis and metabolism; Ethambutol inhibits arabinosyl transferases involved in cell wall synthesis. The combination provides synergistic activity against drug-susceptible and multidrug-resistant tuberculosis.
Approved indications
- Tuberculosis (drug-susceptible and multidrug-resistant forms)
Common side effects
- Gastrointestinal disturbances (nausea, vomiting, diarrhea)
- Hepatotoxicity
- Peripheral neuropathy
- Hyperuricemia
- Optic neuritis (ethambutol-related)
- Photosensitivity (moxifloxacin-related)
Key clinical trials
- Shortened Regimen for Drug-susceptible TB in Children (PHASE3)
- Asymptomatic TB With Innovative Modified Short-course Regimens (PHASE4)
- Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy
- A PAN-USR TB Multi-Center Trial (PHASE3)
- B-PaLMZ for TB Meningitis (PHASE2)
- Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum
- PanACEA - STEP2C -01 (PHASE2)
- Platform Assessing Regimens and Durations In a Global Multisite Consortium for TB (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin CI brief — competitive landscape report
- Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin updates RSS · CI watch RSS
- Global Alliance for TB Drug Development portfolio CI
Frequently asked questions about Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin
What is Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin?
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Is Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin also known as anything else?
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What does Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin target?
Related
- Drug class: All Anti-tuberculosis agent combination drugs
- Target: All drugs targeting Multiple: DNA gyrase (moxifloxacin), RNA polymerase (rifampicin), mycolic acid synthesis (isoniazid, pyrazinamide), arabinosyl transferase (ethambutol)
- Manufacturer: Global Alliance for TB Drug Development — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Tuberculosis (drug-susceptible and multidrug-resistant forms)
- Also known as: Avelox, Avelon, Avalox, Myambutol, Nydrazid
- Compare: Moxifloxacin, Ethambutol, Isoniazid, Pyrazinamide & Rifampicin vs similar drugs
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