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Motrin and narcotic

Cape Fear Valley Health System · FDA-approved active Small molecule

Motrin and narcotic is a NSAID + opioid analgesic combination Small molecule drug developed by Cape Fear Valley Health System. It is currently FDA-approved for Moderate to moderately severe acute pain.

This combination uses ibuprofen to reduce inflammation and pain, while a narcotic opioid provides additional pain relief through central nervous system depression.

This combination uses ibuprofen to reduce inflammation and pain, while a narcotic opioid provides additional pain relief through central nervous system depression. Used for Moderate to moderately severe acute pain.

At a glance

Generic nameMotrin and narcotic
SponsorCape Fear Valley Health System
Drug classNSAID + opioid analgesic combination
TargetCOX-1/COX-2 (ibuprofen); mu, delta, and kappa opioid receptors (narcotic component)
ModalitySmall molecule
Therapeutic areaPain Management
PhaseFDA-approved

Mechanism of action

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, fever, and pain. The narcotic component (opioid) binds to opioid receptors in the central nervous system to modulate pain perception and provide additional analgesia. This combination is used for moderate to moderately severe pain where either agent alone may be insufficient.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Motrin and narcotic

What is Motrin and narcotic?

Motrin and narcotic is a NSAID + opioid analgesic combination drug developed by Cape Fear Valley Health System, indicated for Moderate to moderately severe acute pain.

How does Motrin and narcotic work?

This combination uses ibuprofen to reduce inflammation and pain, while a narcotic opioid provides additional pain relief through central nervous system depression.

What is Motrin and narcotic used for?

Motrin and narcotic is indicated for Moderate to moderately severe acute pain.

Who makes Motrin and narcotic?

Motrin and narcotic is developed and marketed by Cape Fear Valley Health System (see full Cape Fear Valley Health System pipeline at /company/cape-fear-valley-health-system).

What drug class is Motrin and narcotic in?

Motrin and narcotic belongs to the NSAID + opioid analgesic combination class. See all NSAID + opioid analgesic combination drugs at /class/nsaid-opioid-analgesic-combination.

What development phase is Motrin and narcotic in?

Motrin and narcotic is FDA-approved (marketed).

What are the side effects of Motrin and narcotic?

Common side effects of Motrin and narcotic include Nausea, Dizziness, Drowsiness, Constipation, Gastrointestinal upset, Respiratory depression.

What does Motrin and narcotic target?

Motrin and narcotic targets COX-1/COX-2 (ibuprofen); mu, delta, and kappa opioid receptors (narcotic component) and is a NSAID + opioid analgesic combination.

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