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Morphine hydrochloride, Spinal
Morphine hydrochloride, Spinal is a Opioid agonist Small molecule drug developed by South Carelia Central Hospital. It is currently FDA-approved for Severe chronic pain (spinal administration), Cancer pain (intrathecal delivery).
Morphine hydrochloride binds to opioid receptors in the spinal cord to block pain signal transmission.
Morphine hydrochloride binds to opioid receptors in the spinal cord to block pain signal transmission. Used for Chronic pain management via intrathecal administration, Cancer pain, Post-operative pain.
At a glance
| Generic name | Morphine hydrochloride, Spinal |
|---|---|
| Sponsor | South Carelia Central Hospital |
| Drug class | Opioid agonist |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | FDA-approved |
Mechanism of action
When administered intrathecally (into the spinal fluid), morphine acts on mu-opioid receptors located on dorsal horn neurons and other pain-processing neurons in the spinal cord. This binding inhibits the release of neurotransmitters involved in pain signaling and hyperpolarizes neurons, effectively reducing pain perception at the spinal level with lower systemic doses than oral or parenteral administration.
Approved indications
- Severe chronic pain (spinal administration)
- Cancer pain (intrathecal delivery)
Common side effects
- Respiratory depression
- Pruritus
- Nausea and vomiting
- Urinary retention
- Hypotension
- Headache
Key clinical trials
- A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose Chemotherapy Plus Maintenance Over a Longer Amount of Time in Patients With Newly Diagnosed Intermediate-Risk Rhabdomyosarcoma (IR RMS) (PHASE3)
- Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi Analgesia (PHASE3)
- Epidural and Intravenous Patient-Controlled Analgesia Following Lumbar Spinal Fusion Surgery (PHASE4)
- Comparison of Pain Relief Efficacy of Epidural Analgesia and Erector Spinae Plane Block Before Thoracotomy Surgery
- Intraoperative Methadone Administration for Improved Pain Control in Spinal Fusion Patients (PHASE4)
- Reduction of Opioid Dose Using Conditioning & Open-Label Placebo (COLP) in Patients With Spinal Cord Injury, Polytrauma and Burn Injury (PHASE2)
- A Randomized Control Trial Comparing Analgesic Benefits of Ultrasound-guided Single vs Continuous Quadratus Lumborum Blocks (QLB)vs Intrathecal Morphine(ITM) for Post Cesarean Section Pain (PHASE4)
- The Efficacy and Safety of S-ketamine in Elective Cesarean Section (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Morphine hydrochloride, Spinal CI brief — competitive landscape report
- Morphine hydrochloride, Spinal updates RSS · CI watch RSS
- South Carelia Central Hospital portfolio CI
Frequently asked questions about Morphine hydrochloride, Spinal
What is Morphine hydrochloride, Spinal?
How does Morphine hydrochloride, Spinal work?
What is Morphine hydrochloride, Spinal used for?
Who makes Morphine hydrochloride, Spinal?
What drug class is Morphine hydrochloride, Spinal in?
What development phase is Morphine hydrochloride, Spinal in?
What are the side effects of Morphine hydrochloride, Spinal?
What does Morphine hydrochloride, Spinal target?
Related
- Drug class: All Opioid agonist drugs
- Target: All drugs targeting Mu-opioid receptor (μ-OR)
- Manufacturer: South Carelia Central Hospital — full pipeline
- Therapeutic area: All drugs in Pain management
- Indication: Drugs for Severe chronic pain (spinal administration)
- Indication: Drugs for Cancer pain (intrathecal delivery)
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing