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morphine and droperidol
morphine and droperidol is a Opioid analgesic with antipsychotic/antiemetic Small molecule drug developed by Dr.med. Sabine Schoenfeld. It is currently FDA-approved for Moderate to severe acute pain, Perioperative analgesia and anxiolysis. Also known as: DHBP.
Morphine provides opioid analgesia by binding mu opioid receptors, while droperidol is a butyrophenone antipsychotic that blocks dopamine receptors to reduce nausea and anxiety.
Morphine provides opioid analgesia by binding mu opioid receptors, while droperidol is a butyrophenone antipsychotic that blocks dopamine receptors to reduce nausea and anxiety. Used for Moderate to severe acute pain, Perioperative analgesia and anxiolysis.
At a glance
| Generic name | morphine and droperidol |
|---|---|
| Also known as | DHBP |
| Sponsor | Dr.med. Sabine Schoenfeld |
| Drug class | Opioid analgesic with antipsychotic/antiemetic |
| Target | Mu opioid receptor (morphine); dopamine D2 receptor (droperidol) |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Anesthesia |
| Phase | FDA-approved |
Mechanism of action
This combination product pairs morphine, a mu opioid receptor agonist that modulates pain perception in the central nervous system, with droperidol, a dopamine antagonist that provides antiemetic and anxiolytic effects. Droperidol's dopamine blockade at the chemoreceptor trigger zone reduces opioid-induced nausea and vomiting, while also providing sedation and anxiolysis to complement morphine's analgesic action.
Approved indications
- Moderate to severe acute pain
- Perioperative analgesia and anxiolysis
Common side effects
- Respiratory depression
- Hypotension
- Sedation
- Nausea and vomiting
- Dizziness
- QT prolongation (droperidol)
Key clinical trials
- E7 TCR T Cells for Human Papillomavirus-Associated Cancers (PHASE1, PHASE2)
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Lumbar Erector Spinae Plane Block for Back Surgery (PHASE3)
- Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC (PHASE4)
- Efficacy of an Anterior Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia Repair (NA)
- Sublingual Sufentanil Tablet System (SSTS) Versus Intravenous Patient Controlled Analgesia After Back Surgery. (NA)
- Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis (NA)
- Serratus Anterior Plane Block: Post-operative Analgesia in Video-assisted Thoracic Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- morphine and droperidol CI brief — competitive landscape report
- morphine and droperidol updates RSS · CI watch RSS
- Dr.med. Sabine Schoenfeld portfolio CI
Frequently asked questions about morphine and droperidol
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Related
- Drug class: All Opioid analgesic with antipsychotic/antiemetic drugs
- Target: All drugs targeting Mu opioid receptor (morphine); dopamine D2 receptor (droperidol)
- Manufacturer: Dr.med. Sabine Schoenfeld — full pipeline
- Therapeutic area: All drugs in Pain Management, Anesthesia
- Indication: Drugs for Moderate to severe acute pain
- Indication: Drugs for Perioperative analgesia and anxiolysis
- Also known as: DHBP
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing