{"id":"morphine-and-droperidol","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"QT prolongation (droperidol)"}]},"_chembl":{"chemblId":"CHEMBL5665374","moleculeType":null,"molecularWeight":"285.34"},"_fixedAt":"2026-03-30T18:09:13.031760","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination product pairs morphine, a mu opioid receptor agonist that modulates pain perception in the central nervous system, with droperidol, a dopamine antagonist that provides antiemetic and anxiolytic effects. Droperidol's dopamine blockade at the chemoreceptor trigger zone reduces opioid-induced nausea and vomiting, while also providing sedation and anxiolysis to complement morphine's analgesic action.","oneSentence":"Morphine provides opioid analgesia by binding mu opioid receptors, while droperidol is a butyrophenone antipsychotic that blocks dopamine receptors to reduce nausea and anxiety.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:55:50.950Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe acute pain"},{"name":"Perioperative analgesia and anxiolysis"}]},"_fixedFields":["pubmed(204)"],"trialDetails":[{"nctId":"NCT02858310","phase":"PHASE1, PHASE2","title":"E7 TCR T Cells for Human Papillomavirus-Associated Cancers","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2017-01-27","conditions":"Papillomavirus Infections, Cervical Intraepithelial Neoplasia, Carcinoma In Situ","enrollment":224},{"nctId":"NCT04894864","phase":"PHASE4","title":"Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair","status":"RECRUITING","sponsor":"University of Crete","startDate":"2020-10-08","conditions":"Elective Surgical Procedures, Postoperative Pain, Anesthesia","enrollment":40},{"nctId":"NCT03825198","phase":"PHASE3","title":"Lumbar Erector Spinae Plane Block for Back Surgery","status":"UNKNOWN","sponsor":"Dr M. B. Breebaart","startDate":"2019-08-01","conditions":"Pain, Postoperative, Anaesthesia, Surgery","enrollment":80},{"nctId":"NCT05172739","phase":"PHASE4","title":"Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC","status":"RECRUITING","sponsor":"University of Crete","startDate":"2021-10-01","conditions":"Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic","enrollment":70},{"nctId":"NCT03023462","phase":"NA","title":"Efficacy of an Anterior Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia Repair","status":"COMPLETED","sponsor":"Ostfold Hospital Trust","startDate":"2019-09-05","conditions":"Inguinal Hernia, Pain, Postoperative","enrollment":60},{"nctId":"NCT03036514","phase":"NA","title":"Sublingual Sufentanil Tablet System (SSTS) Versus Intravenous Patient Controlled Analgesia After Back Surgery.","status":"COMPLETED","sponsor":"University Hospital, Antwerp","startDate":"2017-04-05","conditions":"Pain, Postoperative","enrollment":27},{"nctId":"NCT02625181","phase":"NA","title":"Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2016-07","conditions":"Postoperative Nausea and Vomiting","enrollment":27034},{"nctId":"NCT03277391","phase":"NA","title":"Serratus Anterior Plane Block: Post-operative Analgesia in Video-assisted Thoracic Surgery","status":"UNKNOWN","sponsor":"Université Libre de Bruxelles","startDate":"2017-04-14","conditions":"Regional Anesthesia, Thoracic Surgery, Post-operative Pain","enrollment":20},{"nctId":"NCT02282956","phase":"PHASE4","title":"Ultrasound Guided Single Shot Block of Posterior Tibial Nerve for Postoperative Pain Relief After Hallux Valgus Surgery","status":"UNKNOWN","sponsor":"Dr.med. Sabine Schoenfeld","startDate":"2014-10","conditions":"Hallux Valgus","enrollment":60},{"nctId":"NCT01592708","phase":"NA","title":"Study of Anesthesia Techniques to Reduce Nausea and Vomiting After Jaw Corrective Surgery","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2012-06","conditions":"Post-operative Nausea, Post-operative Vomiting, Nausea Persistent","enrollment":233},{"nctId":"NCT01470846","phase":"PHASE4","title":"Postoperative Analgesia in Abdominal Surgery: a Medico-economic Study","status":"TERMINATED","sponsor":"University Hospital, Limoges","startDate":"2011-11","conditions":"Extended Ileal Resection Under Laparotomy, Total Proctocolectomy Under Laparotomy, Colectomy Left/Right/Total Under Laparotomy","enrollment":35}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":204,"recentPublications":[{"date":"2025 Nov","pmid":"40782510","title":"Droperidol vs. haloperidol for abdominal pain.","journal":"The American journal of emergency medicine"},{"date":"2025 Mar 24","pmid":"40227606","title":"Reduced Taurine Synthesis Underlies Morphine-Promoted Lung Metastasis of Triple-Negative Breast Cancer.","journal":"Cancers"},{"date":"2025 Mar-Apr","pmid":"40164065","title":"Long-term Physicochemical Stability of a Pharmaceutical Preparation of Morphine Hydrochloride and Droperidol in Polypropylene Syringes.","journal":"International journal of pharmaceutical compounding"},{"date":"2025 Apr","pmid":"39798184","title":"DRopEridol for Abdominal pain in the emergency department for Morphine Equivalent Reduction. The DREAMER study.","journal":"The American journal of emergency medicine"},{"date":"2025 Feb 1","pmid":"39787467","title":"Incidence and influential factors of postoperative pruritus in morphine-based intravenous patient-controlled analgesia.","journal":"Journal of the Chinese Medical Association : JCMA"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["DHBP"],"phase":"marketed","status":"active","brandName":"morphine and droperidol","genericName":"morphine and droperidol","companyName":"Dr.med. Sabine Schoenfeld","companyId":"dr-med-sabine-schoenfeld","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine provides opioid analgesia by binding mu opioid receptors, while droperidol is a butyrophenone antipsychotic that blocks dopamine receptors to reduce nausea and anxiety. Used for Moderate to severe acute pain, Perioperative analgesia and anxiolysis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}