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Monoket Pill
Monoket is an isosorbide mononitrate that releases nitric oxide to dilate blood vessels and reduce cardiac workload in angina.
Monoket is an isosorbide mononitrate that releases nitric oxide to dilate blood vessels and reduce cardiac workload. Used for Prophylaxis and treatment of angina pectoris, Prevention of anginal episodes in patients with coronary artery disease.
At a glance
| Generic name | Monoket Pill |
|---|---|
| Also known as | Isosorbide mononitrate |
| Sponsor | Ohio State University |
| Drug class | Nitrate vasodilator |
| Target | Soluble guanylate cyclase (via nitric oxide) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Isosorbide mononitrate is a nitrate prodrug that is bioconverted to nitric oxide, which activates guanylate cyclase in vascular smooth muscle, leading to vasodilation of coronary and peripheral blood vessels. This reduces preload and afterload on the heart, decreasing myocardial oxygen demand and improving coronary blood flow, thereby relieving anginal symptoms.
Approved indications
- Angina pectoris (prophylaxis and acute relief)
Common side effects
- Headache
- Dizziness
- Hypotension
- Tachycardia
- Nausea
Key clinical trials
- Treatment of Orthostatic Intolerance (PHASE1, PHASE2)
- Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia (PHASE4)
- Curative Effect Evaluation of Shexiang Baoxin Pill on Coronary Artery Disease Not Amenable to Revascularization (PHASE4)
- A Clinical Trials of Quick-Acting Heart Reliever for Moderate Coronary Stenosis (PHASE4)
- Clinical Impact of the Withdrawal of Nitrate in Patients With Stable Angina (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Monoket Pill CI brief — competitive landscape report
- Monoket Pill updates RSS · CI watch RSS
- Ohio State University portfolio CI