{"id":"monoket-pill","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Headache"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-10","effect":"Hypotension"},{"rate":"5","effect":"Tachycardia"},{"rate":"2-5","effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Isosorbide mononitrate is a nitrate prodrug that is bioconverted to nitric oxide, which activates guanylate cyclase in vascular smooth muscle, leading to vasodilation of coronary and peripheral blood vessels. This reduces preload and afterload on the heart, decreasing myocardial oxygen demand and improving coronary blood flow, thereby relieving anginal symptoms.","oneSentence":"Monoket is an isosorbide mononitrate that releases nitric oxide to dilate blood vessels and reduce cardiac workload in angina.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:36.982Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Angina pectoris (prophylaxis and acute relief)"}]},"trialDetails":[{"nctId":"NCT00262470","phase":"PHASE1, PHASE2","title":"Treatment of Orthostatic Intolerance","status":"ACTIVE_NOT_RECRUITING","sponsor":"Satish R. Raj","startDate":"1997-04","conditions":"Tachycardia, Chronic Orthostatic Intolerance","enrollment":150},{"nctId":"NCT03171480","phase":"PHASE4","title":"Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia","status":"COMPLETED","sponsor":"Ohio State University","startDate":"2017-10-30","conditions":"Preeclampsia, Labor, Premature","enrollment":176},{"nctId":"NCT03072121","phase":"PHASE4","title":"Curative Effect Evaluation of Shexiang Baoxin Pill on Coronary Artery Disease Not Amenable to Revascularization","status":"UNKNOWN","sponsor":"Jun Li","startDate":"2017-06","conditions":"Coronary Artery Disease(CAD)","enrollment":440},{"nctId":"NCT01513070","phase":"PHASE4","title":"A Clinical Trials of Quick-Acting Heart Reliever for Moderate Coronary Stenosis","status":"COMPLETED","sponsor":"Guang'anmen Hospital of China Academy of Chinese Medical Sciences","startDate":"2012-04","conditions":"Coronary Artery Stenosis, Coronary Heart Disease","enrollment":120},{"nctId":"NCT01769079","phase":"PHASE4","title":"Clinical Impact of the Withdrawal of Nitrate in Patients With Stable Angina","status":"COMPLETED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2009-09","conditions":"Stable Angina, Myocardial Ischemia, Quality of Life","enrollment":95}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Isosorbide mononitrate"],"phase":"marketed","status":"active","brandName":"Monoket Pill","genericName":"Monoket Pill","companyName":"Ohio State University","companyId":"ohio-state-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Monoket is an isosorbide mononitrate that releases nitric oxide to dilate blood vessels and reduce cardiac workload. Used for Prophylaxis and treatment of angina pectoris, Prevention of anginal episodes in patients with coronary artery disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}