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Mix of 50% oxygen and 50% nitrogen
Mix of 50% oxygen and 50% nitrogen is a Medical gas Small molecule drug developed by Air Liquide Santé International. It is currently FDA-approved for Supplemental oxygen therapy in anesthesia and critical care, Reduction of atelectasis during general anesthesia, Oxygen therapy with reduced hyperoxia risk.
A 50:50 oxygen-nitrogen gas mixture provides supplemental oxygen while reducing the partial pressure of oxygen to minimize hyperoxia-related complications.
A 50:50 oxygen-nitrogen gas mixture provides supplemental oxygen while reducing the partial pressure of oxygen to minimize hyperoxia-related complications. Used for Supplemental oxygen therapy in anesthesia and critical care, Reduction of atelectasis during general anesthesia, Oxygen therapy with reduced hyperoxia risk.
At a glance
| Generic name | Mix of 50% oxygen and 50% nitrogen |
|---|---|
| Sponsor | Air Liquide Santé International |
| Drug class | Medical gas |
| Modality | Small molecule |
| Therapeutic area | Respiratory/Anesthesia |
| Phase | FDA-approved |
Mechanism of action
This gas mixture delivers therapeutic oxygen to tissues while the nitrogen component dilutes the oxygen concentration, reducing the risk of oxygen toxicity and absorption atelectasis. It is commonly used in medical settings where controlled oxygenation is needed without the risks associated with high-concentration pure oxygen therapy.
Approved indications
- Supplemental oxygen therapy in anesthesia and critical care
- Reduction of atelectasis during general anesthesia
- Oxygen therapy with reduced hyperoxia risk
Common side effects
- Hyperoxia (minimized by nitrogen dilution)
- Absorption atelectasis (reduced compared to pure oxygen)
Key clinical trials
- A Randomized, Placebo-controlled Trial of Nitrous Oxide During In-office Bladder Botox Injections (PHASE4)
- Recovery After Dialysis-Requiring Acute Kidney Injury (NA)
- Use of 50% Nitrous Oxide / 50% Oxygen Premix During Liver Biopsy of Focal Lesion (PHASE4)
- A Single-centre Study of Entonox Versus Midazolam Sedation in Gastroscopy (PHASE4)
- Pethidine Versus Nitrous Oxide for Pain Relief During Labor (NA)
- Adjunctive Nitrous Oxide During ED Incision and Drainage of Abscess (NA)
- Nitrous Oxide for Major Depressive Disorder (PHASE2)
- Adjunctive Nitrous Oxide During Emergency Department Propofol Sedation in Adults (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Mix of 50% oxygen and 50% nitrogen CI brief — competitive landscape report
- Mix of 50% oxygen and 50% nitrogen updates RSS · CI watch RSS
- Air Liquide Santé International portfolio CI
Frequently asked questions about Mix of 50% oxygen and 50% nitrogen
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Related
- Drug class: All Medical gas drugs
- Manufacturer: Air Liquide Santé International — full pipeline
- Therapeutic area: All drugs in Respiratory/Anesthesia
- Indication: Drugs for Supplemental oxygen therapy in anesthesia and critical care
- Indication: Drugs for Reduction of atelectasis during general anesthesia
- Indication: Drugs for Oxygen therapy with reduced hyperoxia risk
- Compare: Mix of 50% oxygen and 50% nitrogen vs similar drugs
- Pricing: Mix of 50% oxygen and 50% nitrogen cost, discount & access