{"id":"mix-of-50-oxygen-and-50-nitrogen","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperoxia (minimized by nitrogen dilution)"},{"rate":null,"effect":"Absorption atelectasis (reduced compared to pure oxygen)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This gas mixture delivers therapeutic oxygen to tissues while the nitrogen component dilutes the oxygen concentration, reducing the risk of oxygen toxicity and absorption atelectasis. It is commonly used in medical settings where controlled oxygenation is needed without the risks associated with high-concentration pure oxygen therapy.","oneSentence":"A 50:50 oxygen-nitrogen gas mixture provides supplemental oxygen while reducing the partial pressure of oxygen to minimize hyperoxia-related complications.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:55:28.774Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Supplemental oxygen therapy in anesthesia and critical care"},{"name":"Reduction of atelectasis during general anesthesia"},{"name":"Oxygen therapy with reduced hyperoxia risk"}]},"trialDetails":[{"nctId":"NCT07387315","phase":"PHASE4","title":"A Randomized, Placebo-controlled Trial of Nitrous Oxide During In-office Bladder Botox Injections","status":"NOT_YET_RECRUITING","sponsor":"TriHealth Inc.","startDate":"2026-02","conditions":"Overactive Bladder, Neurogenic Bladder, Urge Incontinence","enrollment":96},{"nctId":"NCT03305549","phase":"NA","title":"Recovery After Dialysis-Requiring Acute Kidney Injury","status":"TERMINATED","sponsor":"University of California, San Francisco","startDate":"2017-09-29","conditions":"Acute Kidney Injury","enrollment":16},{"nctId":"NCT00643656","phase":"PHASE4","title":"Use of 50% Nitrous Oxide / 50% Oxygen Premix During Liver Biopsy of Focal Lesion","status":"COMPLETED","sponsor":"Air Liquide Santé International","startDate":"2007-10","conditions":"Liver Biopsy","enrollment":94},{"nctId":"NCT01744184","phase":"PHASE4","title":"A Single-centre Study of Entonox Versus Midazolam Sedation in Gastroscopy","status":"TERMINATED","sponsor":"The Royal Bournemouth Hospital","startDate":"2013-05","conditions":"Patients Requiring Diagnostic Gastroscopy With Sedation","enrollment":62},{"nctId":"NCT02783508","phase":"NA","title":"Pethidine Versus Nitrous Oxide for Pain Relief During Labor","status":"COMPLETED","sponsor":"HaEmek Medical Center, Israel","startDate":"2016-08","conditions":"Labor Pain","enrollment":214},{"nctId":"NCT03127371","phase":"NA","title":"Adjunctive Nitrous Oxide During ED Incision and Drainage of Abscess","status":"TERMINATED","sponsor":"Albert Einstein Healthcare Network","startDate":"2016-09","conditions":"Abscess","enrollment":41},{"nctId":"NCT03932825","phase":"PHASE2","title":"Nitrous Oxide for Major Depressive Disorder","status":"COMPLETED","sponsor":"Lingjiang Li","startDate":"2019-04-01","conditions":"Depressive Disorder, Major Depressive Disorder, Treatment Resistant Depression","enrollment":44},{"nctId":"NCT02410707","phase":"NA","title":"Adjunctive Nitrous Oxide During Emergency Department Propofol Sedation in Adults","status":"COMPLETED","sponsor":"Albert Einstein Healthcare Network","startDate":"2015-02","conditions":"Joint Dislocation, Perianal Abscess, Abscess","enrollment":43},{"nctId":"NCT00219713","phase":"PHASE3","title":"Evaluation of Pain Intensity During Bone Marrow Biopsy Performed With Inhalation of Pre-Mixed 50 Per Cent Nitrous Oxide and Oxygen Mixture.","status":"TERMINATED","sponsor":"Poitiers University Hospital","startDate":"2000-03","conditions":"Pain","enrollment":280}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Mix of 50% oxygen and 50% nitrogen","genericName":"Mix of 50% oxygen and 50% nitrogen","companyName":"Air Liquide Santé International","companyId":"air-liquide-sant-international","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A 50:50 oxygen-nitrogen gas mixture provides supplemental oxygen while reducing the partial pressure of oxygen to minimize hyperoxia-related complications. Used for Supplemental oxygen therapy in anesthesia and critical care, Reduction of atelectasis during general anesthesia, Oxygen therapy with reduced hyperoxia risk.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}