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Misoprostol Oral Tablet
Misoprostol is a prostaglandin E1 analog that increases gastric mucus production and bicarbonate secretion while reducing gastric acid secretion.
Misoprostol is a prostaglandin E1 analog that increases gastric mucus production and bicarbonate secretion while reducing gastric acid secretion. Used for Prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers, Treatment of gastric ulcers, Medical abortion (in combination with mifepristone).
At a glance
| Generic name | Misoprostol Oral Tablet |
|---|---|
| Also known as | Oral Cytotec, two tablets of Cytotec (200 μg), cytotec, Misotac, Misoprost |
| Sponsor | Bnai Zion Medical Center |
| Drug class | Prostaglandin analog |
| Target | Prostaglandin E1 receptor (EP receptor) |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology; Obstetrics/Gynecology |
| Phase | FDA-approved |
Mechanism of action
Misoprostol binds to prostaglandin receptors on gastric mucosa cells, enhancing protective mechanisms against acid damage. It also promotes gastric blood flow and stimulates mucus and bicarbonate secretion, creating a protective barrier. Additionally, it has cytoprotective effects that help prevent ulcer formation and promote healing of existing ulcers.
Approved indications
- Prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers
- Treatment of gastric and duodenal ulcers
- Off-label use for medical abortion (in combination with mifepristone)
Common side effects
- Diarrhea
- Abdominal pain
- Nausea
- Flatulence
- Headache
- Uterine contractions (in women of childbearing potential)
Key clinical trials
- Combined Use of Oxytocin and Misoprostol in the Prevention of Post Partum Haemorrhage (PHASE4)
- A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion (NA)
- Oxytocin vs Prostaglandins for Labor Induction of Women With an Unfavorable Cervix After 24h of Cervical Ripening (PHASE3)
- Interest of Cervical Dilators in Second Trimester Termination of Pregnancy (NA)
- Ultrasound-guided Manual Vacuum Aspiration (USG-MVA)
- Comparison Between Vaginal Misoprostol Gel and Oral Misoprostol Solution in Induction of Labor (EARLY_PHASE1)
- Prevention of Recurrent Ulcer Bleeding in Patients With Idiopathic Gastroduodenal Ulcer (PHASE4)
- Labor Induction With Double Balloon Device, Oral Misoprostol and Concomitant Use of Both (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |