{"id":"misoprostol-oral-tablet","safety":{"commonSideEffects":[{"rate":"10-30","effect":"Diarrhea"},{"rate":"5-20","effect":"Abdominal pain"},{"rate":"3-14","effect":"Nausea"},{"rate":"2-10","effect":"Flatulence"},{"rate":"2-7","effect":"Headache"},{"rate":null,"effect":"Uterine contractions (in women of childbearing potential)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Misoprostol binds to prostaglandin receptors on gastric mucosa cells, enhancing protective mechanisms against acid damage. It also promotes gastric blood flow and stimulates mucus and bicarbonate secretion, creating a protective barrier. Additionally, it has cytoprotective effects that help prevent ulcer formation and promote healing of existing ulcers.","oneSentence":"Misoprostol is a prostaglandin E1 analog that increases gastric mucus production and bicarbonate secretion while reducing gastric acid secretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:27.770Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers"},{"name":"Treatment of gastric and duodenal ulcers"},{"name":"Off-label use for medical abortion (in combination with mifepristone)"}]},"trialDetails":[{"nctId":"NCT01113229","phase":"PHASE4","title":"Combined Use of Oxytocin and Misoprostol in the Prevention of Post Partum Haemorrhage","status":"TERMINATED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2010-03","conditions":"Hemorrhage; Complicating 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Solution","status":"COMPLETED","sponsor":"Christian Medical College and Hospital, Ludhiana, India","startDate":"2017-12-01","conditions":"Induction of Labor","enrollment":264},{"nctId":"NCT03708497","phase":"NA","title":"Carbetocin Versus Oral Tranexamic Acid Plus, Buccal Misoprostol on Blood Loss After Vaginal Delivery","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2018-12-01","conditions":"Postpartum Hemorrhage","enrollment":360},{"nctId":"NCT03962283","phase":"PHASE2, PHASE3","title":"Rifaximin and Misoprostol Combination Therapy for Healing of Small Bowel Ulcers in Aspirin Users","status":"UNKNOWN","sponsor":"Chinese University of Hong Kong","startDate":"2019-08-02","conditions":"Small Bowel Disease, Rifaximin","enrollment":78},{"nctId":"NCT03065660","phase":"PHASE3","title":"Mifepristone and Misoprostol Versus Misoprostol Alone in the Medical Management of Missed Miscarriage","status":"COMPLETED","sponsor":"University of 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Used for Prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers, Treatment of gastric ulcers, Medical abortion (in combination with mifepristone).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":3,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}