Last reviewed 2026-04-22 · How we verify

Minocycline,Metronidazole

Minocycline,Metronidazole is a Combination antibiotic Small molecule drug developed by Shanghai Jiao Tong University School of Medicine. It is currently FDA-approved for Polymicrobial infections, Acne and rosacea (off-label combination use), Anaerobic bacterial infections.

This combination of minocycline (a tetracycline antibiotic) and metronidazole (a nitroimidazole antimicrobial) works synergistically to inhibit bacterial protein synthesis and DNA/RNA metabolism, respectively, providing broad-spectrum antimicrobial coverage.

Minocycline and metronidazole are a combination of a tetracycline antibiotic and a nitroimidazole antimicrobial that work together to inhibit bacterial protein synthesis and DNA/RNA synthesis, respectively. Used for Bacterial infections (aerobic and anaerobic), Mixed bacterial infections.

At a glance

Mechanism of action

Minocycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, while metronidazole is reduced by anaerobic bacteria to form reactive intermediates that damage DNA and RNA. Together, they provide enhanced activity against a broader range of aerobic and anaerobic bacteria, commonly used in polymicrobial infections and certain dermatological conditions.

Approved indications

• Polymicrobial infections
• Acne and rosacea (off-label combination use)
• Anaerobic bacterial infections

Common side effects

• Gastrointestinal upset (nausea, diarrhea)
• Photosensitivity (minocycline)
• Metallic taste (metronidazole)
• Headache
• Vaginal candidiasis

Key clinical trials

• Optimization of Minocycline for Helicobacter Pylori Rescue Treatment (PHASE4)
• Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment (NA)
• Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment (PHASE3)
• Fecal Molecular Susceptibility-guided Hp First-line Therapy (PHASE4)
• Fecal Molecular Susceptibility-guided Hp Rescue Therapy (PHASE4)
• Comparing the Efficacy of Metronidazole and Minocycline Gels for the Treatment of Diabetic Periodontitis Patients (NA)
• To Measure Post Operative Pain Severity by Using Two Different Intra Canal Medicaments Calcium Hydroxide and Triple Antibiotic Paste in Teeth with Single Roots and Periapical Disease Called Apical Periodontitis (PHASE2, PHASE3)
• Success of Lesion Sterilization and Tissue Repair Therapy (PHASE4)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Minocycline,Metronidazole CI brief — competitive landscape report
• Minocycline,Metronidazole updates RSS · CI watch RSS
• Shanghai Jiao Tong University School of Medicine portfolio CI

Frequently asked questions about Minocycline,Metronidazole

Related

• Drug class: All Combination antibiotic drugs
• Target: All drugs targeting Bacterial 30S ribosome (minocycline); microbial DNA/RNA (metronidazole)
• Manufacturer: Shanghai Jiao Tong University School of Medicine — full pipeline
• Therapeutic area: All drugs in Infectious Disease
• Indication: Drugs for Polymicrobial infections
• Indication: Drugs for Acne and rosacea (off-label combination use)
• Indication: Drugs for Anaerobic bacterial infections
• Compare: Minocycline,Metronidazole vs similar drugs
• Pricing: Minocycline,Metronidazole cost, discount & access