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Mifepristone plus two doses Misoprostol
Mifepristone blocks progesterone receptors to halt pregnancy, followed by misoprostol doses that induce uterine contractions to expel pregnancy tissue.
Mifepristone blocks progesterone receptors to halt pregnancy, followed by misoprostol doses that induce uterine contractions to expel pregnancy tissue. Used for Medical abortion in early pregnancy (up to 10 weeks gestation).
At a glance
| Generic name | Mifepristone plus two doses Misoprostol |
|---|---|
| Sponsor | Planned Parenthood League of Massachusetts |
| Drug class | Progesterone receptor antagonist + prostaglandin analog combination |
| Target | Progesterone receptor (PR); prostaglandin E1 receptor (EP receptor) |
| Modality | Small molecule |
| Therapeutic area | Reproductive Health / Obstetrics |
| Phase | Phase 3 |
Mechanism of action
Mifepristone is a selective progesterone receptor antagonist that terminates early pregnancy by blocking progesterone's effects on the uterus, causing decidualization reversal and detachment of the conceptus. Misoprostol, a prostaglandin analog, is then administered in two doses to stimulate uterine contractions and facilitate expulsion of pregnancy tissue through the cervix.
Approved indications
- Medical abortion in early pregnancy (up to 10 weeks gestation)
Common side effects
- Vaginal bleeding/heavy menstrual-like bleeding
- Abdominal pain/cramping
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
- Fever/chills
Key clinical trials
- A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion (NA)
- Mifepristone and Misoprostol for Undesired Pregnancy of Unknown Location (PHASE3)
- Mifepristone and Two Doses of Misoprostol for Abortion at 11&12 Weeks (PHASE4)
- Assessing Outpatient 'Day Procedure' for Second-trimester Medical Abortion at Two Public Sector Hospitals in Nepal (PHASE4)
- Comparing Two Medical Treatments for Early Pregnancy Failure. (PHASE4)
- Outpatient Service for Mid-trimester Termination of Pregnancy (PHASE4)
- Comparing Two Regimens for Medical Abortion: Mifepristone + Misoprostol Versus Misoprostol Alone (PHASE4)
- Misoprostol for Second Trimester Termination of Pregnancy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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