{"id":"mifepristone-plus-two-doses-misoprostol","safety":{"commonSideEffects":[{"rate":"90-95","effect":"Vaginal bleeding/heavy menstrual-like bleeding"},{"rate":"85-90","effect":"Abdominal pain/cramping"},{"rate":"50-60","effect":"Nausea"},{"rate":"20-30","effect":"Vomiting"},{"rate":"20-30","effect":"Diarrhea"},{"rate":"10-20","effect":"Headache"},{"rate":"10-15","effect":"Dizziness"},{"rate":"5-10","effect":"Fever/chills"}]},"_chembl":{"chemblId":"CHEMBL4064157","moleculeType":"Small molecule","molecularWeight":"382.54"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Mifepristone is a selective progesterone receptor antagonist that terminates early pregnancy by blocking progesterone's effects on the uterus, causing decidualization reversal and detachment of the conceptus. Misoprostol, a prostaglandin analog, is then administered in two doses to stimulate uterine contractions and facilitate expulsion of pregnancy tissue through the cervix.","oneSentence":"Mifepristone blocks progesterone receptors to halt pregnancy, followed by misoprostol doses that induce uterine contractions to expel pregnancy tissue.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:21:28.054Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Medical abortion in early pregnancy (up to 10 weeks gestation)"}]},"trialDetails":[{"nctId":"NCT07422506","phase":"NA","title":"A Real-World Study Comparing the Efficacy of Different Treatment Regimens for Early Missed Abortion","status":"RECRUITING","sponsor":"The Third Xiangya Hospital of Central South University","startDate":"2024-01-01","conditions":"Missed Abortion, Early Pregnancy Failure","enrollment":580},{"nctId":"NCT05839899","phase":"PHASE3","title":"Mifepristone and Misoprostol for Undesired Pregnancy of Unknown Location","status":"UNKNOWN","sponsor":"Planned Parenthood League of Massachusetts","startDate":"2023-08-30","conditions":"Abortion","enrollment":50},{"nctId":"NCT05119439","phase":"PHASE4","title":"Mifepristone and Two Doses of Misoprostol for Abortion at 11&12 Weeks","status":"TERMINATED","sponsor":"Gynuity Health Projects","startDate":"2022-10-07","conditions":"Medical Abortion","enrollment":23},{"nctId":"NCT05046041","phase":"PHASE4","title":"Assessing Outpatient 'Day Procedure' for Second-trimester Medical Abortion at Two Public Sector Hospitals in Nepal","status":"COMPLETED","sponsor":"Gynuity Health Projects","startDate":"2020-11-25","conditions":"Abortion in Second Trimester","enrollment":120},{"nctId":"NCT03212352","phase":"PHASE4","title":"Comparing Two Medical Treatments for Early Pregnancy Failure.","status":"TERMINATED","sponsor":"Radboud University Medical Center","startDate":"2018-06-27","conditions":"Early Pregnancy Failure","enrollment":342},{"nctId":"NCT03346629","phase":"PHASE4","title":"Outpatient Service for Mid-trimester Termination of Pregnancy","status":"COMPLETED","sponsor":"Gynuity Health Projects","startDate":"2017-12-01","conditions":"Abortion in Second Trimester","enrollment":230},{"nctId":"NCT01387256","phase":"PHASE4","title":"Comparing Two Regimens for Medical Abortion: Mifepristone + Misoprostol Versus Misoprostol Alone","status":"COMPLETED","sponsor":"Gynuity Health Projects","startDate":"2009-05","conditions":"Complete Abortion","enrollment":441},{"nctId":"NCT00945997","phase":"NA","title":"Misoprostol for Second Trimester Termination of Pregnancy","status":"COMPLETED","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2000-10","conditions":"Termination of Pregnancy Second Trimester","enrollment":176}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Mifepristone plus two doses Misoprostol","genericName":"Mifepristone plus two doses Misoprostol","companyName":"Planned Parenthood League of Massachusetts","companyId":"planned-parenthood-league-of-massachusetts","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mifepristone blocks progesterone receptors to halt pregnancy, followed by misoprostol doses that induce uterine contractions to expel pregnancy tissue. Used for Medical abortion in early pregnancy (up to 10 weeks gestation).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}