Last reviewed 2026-04-23 · How we verify

Micronized purified flavonoid fraction

Micronized purified flavonoid fraction is a Bioflavonoid Small molecule drug developed by Pirogov Russian National Research Medical University. It is currently in Phase 3 development for Chronic venous insufficiency, Lymphedema, Hemorrhoids. Also known as: Endovenous Mechano-Chemical Ablation, Venixxa group.

Micronized purified flavonoid fraction improves venous and lymphatic microcirculation by strengthening capillary walls and reducing vascular permeability.

Micronized purified flavonoid fraction improves venous and lymphatic microcirculation by strengthening capillary walls and reducing vascular permeability. Used for Chronic venous insufficiency, Lymphedema, Hemorrhoids.

At a glance

Mechanism of action

This drug is a standardized extract of bioflavonoids that acts on the microvasculature to enhance endothelial function and reduce capillary fragility. It works primarily through antioxidant and anti-inflammatory mechanisms, improving blood flow in small vessels and reducing edema. The micronization process increases bioavailability and therapeutic efficacy.

Approved indications

• Chronic venous insufficiency
• Lymphedema
• Hemorrhoids
• Microangiopathy

Common side effects

• Gastrointestinal upset
• Headache
• Dizziness

Key clinical trials

• Glue Embolization vs Conservative Treatment for Pelvic Congestion Syndrome (NA)
• Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery (PHASE4)
• The Effect of Oral Administration of Hesperidin and Diosmin in Reducing Paclitaxel-induced Peripheral Neuropathy in Breast Cancer Patients (PHASE3)
• Venoactive Drug Treatment of Pelvic Venous Disorders (PHASE3)
• The Efficacy of Aescin in Combination With Micronized Purified Flavonoid Fraction (MPFF) in the Control of Bleeding and Prevent Recurrence of Acute Internal Hemorrhoids, A Randomized Controlled Trial, A Pilot Study (EARLY_PHASE1)
• The Efficacy of Aescin in Combination With MPFF in the Early Control of Bleeding From Acute Internal Hemorrhoids, A Randomized Controlled Trial (NA)
• The MUFFIN-PTS Trial (PHASE3)
• Surgical Approach for Acute External Thrombosed Hemorrhoidal Disease

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Micronized purified flavonoid fraction CI brief — competitive landscape report
• Micronized purified flavonoid fraction updates RSS · CI watch RSS
• Pirogov Russian National Research Medical University portfolio CI

Frequently asked questions about Micronized purified flavonoid fraction

Related

• Drug class: All Bioflavonoid drugs
• Manufacturer: Pirogov Russian National Research Medical University — full pipeline
• Therapeutic area: All drugs in Cardiovascular
• Indication: Drugs for Chronic venous insufficiency
• Indication: Drugs for Lymphedema
• Indication: Drugs for Hemorrhoids
• Also known as: Endovenous Mechano-Chemical Ablation, Venixxa group
• Compare: Micronized purified flavonoid fraction vs similar drugs
• Pricing: Micronized purified flavonoid fraction cost, discount & access