{"id":"micronized-purified-flavonoid-fraction","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This drug is a standardized extract of bioflavonoids that acts on the microvasculature to enhance endothelial function and reduce capillary fragility. It works primarily through antioxidant and anti-inflammatory mechanisms, improving blood flow in small vessels and reducing edema. The micronization process increases bioavailability and therapeutic efficacy.","oneSentence":"Micronized purified flavonoid fraction improves venous and lymphatic microcirculation by strengthening capillary walls and reducing vascular permeability.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:50:02.011Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic venous insufficiency"},{"name":"Lymphedema"},{"name":"Hemorrhoids"},{"name":"Microangiopathy"}]},"trialDetails":[{"nctId":"NCT06560294","phase":"NA","title":"Glue Embolization vs Conservative Treatment for Pelvic Congestion Syndrome","status":"RECRUITING","sponsor":"Tanta University","startDate":"2024-08-17","conditions":"Glue Embolization, Pelvic Congestion Syndrome","enrollment":40},{"nctId":"NCT06184438","phase":"PHASE4","title":"Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery","status":"COMPLETED","sponsor":"Taipei Medical University Shuang Ho Hospital","startDate":"2023-12-13","conditions":"Anal Fistula","enrollment":106},{"nctId":"NCT06811220","phase":"PHASE3","title":"The Effect of Oral Administration of Hesperidin and Diosmin in Reducing Paclitaxel-induced Peripheral Neuropathy in Breast Cancer Patients","status":"NOT_YET_RECRUITING","sponsor":"Alexandria University","startDate":"2025-01-27","conditions":"Breast Cancer","enrollment":140},{"nctId":"NCT06584799","phase":"PHASE3","title":"Venoactive Drug Treatment of Pelvic Venous Disorders","status":"RECRUITING","sponsor":"Pirogov Russian National Research Medical University","startDate":"2024-12","conditions":"Pelvic Venous Disorders","enrollment":150},{"nctId":"NCT06748014","phase":"EARLY_PHASE1","title":"The Efficacy of Aescin in Combination With Micronized Purified Flavonoid Fraction (MPFF) in the Control of Bleeding and Prevent Recurrence of Acute Internal Hemorrhoids, A Randomized Controlled Trial, A Pilot Study","status":"ENROLLING_BY_INVITATION","sponsor":"Chiang Mai University","startDate":"2024-12-20","conditions":"Hemorrhoid","enrollment":120},{"nctId":"NCT06363513","phase":"NA","title":"The Efficacy of Aescin in Combination With MPFF in the Early Control of Bleeding From Acute Internal Hemorrhoids, A Randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"Chiang Mai University","startDate":"2024-04","conditions":"Anorectal Disorder","enrollment":60},{"nctId":"NCT03833024","phase":"PHASE3","title":"The MUFFIN-PTS Trial","status":"UNKNOWN","sponsor":"Sir Mortimer B. Davis - Jewish General Hospital","startDate":"2022-02-04","conditions":"Post-Thrombotic Syndrome","enrollment":88},{"nctId":"NCT06009133","phase":"","title":"Surgical Approach for Acute External Thrombosed Hemorrhoidal Disease","status":"COMPLETED","sponsor":"Konya Meram State Hospital","startDate":"2022-07-01","conditions":"Hemorrhoids External Thrombosed","enrollment":132},{"nctId":"NCT04360889","phase":"PHASE4","title":"Lipid Peroxidation and Options Antioxidant Therapy for Secondary Lymphedema of the Lower Extremities","status":"COMPLETED","sponsor":"Ryazan State Medical University","startDate":"2019-09-01","conditions":"Lower Extremity Lymphedema","enrollment":120},{"nctId":"NCT05243706","phase":"PHASE3","title":"Evaluation of The Effect of Loratadine Versus Diosmin/Hesperidin Combination on Vinca Alkaloids Induced Neuropathy","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2022-03-01","conditions":"Vinca Alkaloid Adverse Reaction","enrollment":90},{"nctId":"NCT04434274","phase":"","title":"MIcronized Flavonoid Fraction After MechanO-Chemical Ablation","status":"UNKNOWN","sponsor":"Belarusian State Medical University","startDate":"2019-01-01","conditions":"Varicose Veins, Surgery","enrollment":100},{"nctId":"NCT04882228","phase":"PHASE4","title":"Phase 4 Study to Evaluate Efficacy and Safety of Entelon Tab.150mg in Patients With Chronic Venous Disease(CVD)","status":"UNKNOWN","sponsor":"Hanlim Pharm. Co., Ltd.","startDate":"2021-01-28","conditions":"Chronic Venous Disease","enrollment":278},{"nctId":"NCT04335617","phase":"PHASE3","title":"Micronized Purified Flavonoid- Fraction (MPFF) in the Management of Radiation Proctitis","status":"UNKNOWN","sponsor":"Medical University Innsbruck","startDate":"2020-02-26","conditions":"Proctitis Radiation","enrollment":200},{"nctId":"NCT02907320","phase":"PHASE2","title":"EXPLORATORY ASSESSMENT OF THE EFFECTS OF CYCLO 3 ® FORT (Ruscus Extract, Hesperidin Methyl Chalcone, Ascorbic Acid) OR MICRONISED PURIFIED FLAVONOID FRACTION ON VASCULAR PARAMETERS AND BIOMARKERS IN WOMEN SUFFERING FROM CHRONIC VENOUS DISEASE (CEAP C2 OR C3), OVER 8 WEEKS","status":"WITHDRAWN","sponsor":"Pierre Fabre Medicament","startDate":"2016-12","conditions":"Venous Disease Classification (CEAP): C2 or C3","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Endovenous Mechano-Chemical Ablation","Venixxa group"],"phase":"phase_3","status":"active","brandName":"Micronized purified flavonoid fraction","genericName":"Micronized purified flavonoid fraction","companyName":"Pirogov Russian National Research Medical University","companyId":"pirogov-russian-national-research-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Micronized purified flavonoid fraction improves venous and lymphatic microcirculation by strengthening capillary walls and reducing vascular permeability. Used for Chronic venous insufficiency, Lymphedema, Hemorrhoids.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}