Last reviewed · How we verify
MgSO4 plus Ropivacaine
Magnesium sulfate enhances the local anesthetic effect of ropivacaine by potentiating neural blockade and reducing pain transmission.
Magnesium sulfate enhances the local anesthetic effect of ropivacaine by potentiating neural blockade and reducing pain transmission. Used for Regional anesthesia and analgesia (peripheral nerve blocks, epidural anesthesia), Postoperative pain management.
At a glance
| Generic name | MgSO4 plus Ropivacaine |
|---|---|
| Sponsor | Hospital Universiti Sains Malaysia |
| Drug class | Local anesthetic adjuvant combination |
| Target | Voltage-gated sodium channels (ropivacaine); NMDA receptors and calcium channels (magnesium sulfate) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Magnesium acts as a natural NMDA receptor antagonist and modulates calcium influx in nerve cells, which synergizes with ropivacaine's sodium channel blockade to prolong anesthesia duration and improve anesthetic efficacy. This combination is used in regional anesthesia to achieve superior sensory and motor blockade with potentially reduced systemic toxicity of the local anesthetic agent.
Approved indications
- Regional anesthesia and analgesia (peripheral nerve blocks, epidural anesthesia)
- Postoperative pain management
Common side effects
- Transient neurological symptoms
- Hypotension
- Bradycardia
- Nausea
- Local anesthetic systemic toxicity (LAST)
Key clinical trials
- The Efficacy and Safety of Magnesium Sulphate Adjuvant in Scalp Block With Ropivacaine for Supratentorial Craniotomy: a Prospective, Randomized Controlled Trial (PHASE4)
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Magnesium as Adjuvant for Sciatic Block (NA)
- Ropivacaine Plus Magnesium Sulphate Infiltration (PHASE4)
- Respiratory Impact of LA Volume After IS Block (PHASE4)
- Bilateral Transversus Abdominis Plane Block With or Without Magnesium (PHASE4)
- Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Plus Ropivacaine for Pain Relief After Spine Surgery (PHASE4)
- Analgesic Efficacy of Continuous Infusion of Local Anaesthetic Versus Single-shot Injection Interscalene Block (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- MgSO4 plus Ropivacaine CI brief — competitive landscape report
- MgSO4 plus Ropivacaine updates RSS · CI watch RSS
- Hospital Universiti Sains Malaysia portfolio CI