{"id":"mgso4-plus-ropivacaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient neurological symptoms"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Local anesthetic systemic toxicity (LAST)"}]},"_chembl":null,"_fixedAt":"2026-03-30T17:44:09.219754","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Magnesium acts as a natural NMDA receptor antagonist and modulates calcium influx in nerve cells, which synergizes with ropivacaine's sodium channel blockade to prolong anesthesia duration and improve anesthetic efficacy. This combination is used in regional anesthesia to achieve superior sensory and motor blockade with potentially reduced systemic toxicity of the local anesthetic agent.","oneSentence":"Magnesium sulfate enhances the local anesthetic effect of ropivacaine by potentiating neural blockade and reducing pain transmission.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:55:09.734Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Regional anesthesia and analgesia (peripheral nerve blocks, epidural anesthesia)"},{"name":"Postoperative pain management"}]},"_fixedFields":["pubmed(11)"],"trialDetails":[{"nctId":"NCT07075783","phase":"PHASE4","title":"The Efficacy and Safety of Magnesium Sulphate Adjuvant in Scalp Block With Ropivacaine for Supratentorial Craniotomy: a Prospective, Randomized Controlled Trial","status":"COMPLETED","sponsor":"Hospital Universiti Sains Malaysia","startDate":"2024-10-03","conditions":"Efficacy and Safety of MgSO4 as Adjuvant to Scalp Block","enrollment":24},{"nctId":"NCT04894864","phase":"PHASE4","title":"Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair","status":"RECRUITING","sponsor":"University of Crete","startDate":"2020-10-08","conditions":"Elective Surgical Procedures, Postoperative Pain, Anesthesia","enrollment":40},{"nctId":"NCT02198547","phase":"NA","title":"Magnesium as Adjuvant for Sciatic Block","status":"COMPLETED","sponsor":"Campus Bio-Medico University","startDate":"2014-03","conditions":"Hallux Valgus","enrollment":60},{"nctId":"NCT05294393","phase":"PHASE4","title":"Ropivacaine Plus Magnesium Sulphate Infiltration","status":"COMPLETED","sponsor":"Aristotle University Of Thessaloniki","startDate":"2022-01-19","conditions":"Thyroid Diseases, Parathyroid Diseases, Postoperative Pain","enrollment":68},{"nctId":"NCT04726280","phase":"PHASE4","title":"Respiratory Impact of LA Volume After IS Block","status":"COMPLETED","sponsor":"Eric Albrecht","startDate":"2021-02-01","conditions":"Arthroscopic Surgery of the Shoulder, Extrafascial Interscalene Plexus Brachial Block","enrollment":60},{"nctId":"NCT02680626","phase":"PHASE4","title":"Bilateral Transversus Abdominis Plane Block With or Without Magnesium","status":"TERMINATED","sponsor":"Dr. Anthony Ho","startDate":"2016-01","conditions":"Pain, Postoperative","enrollment":86},{"nctId":"NCT04391855","phase":"PHASE4","title":"Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Plus Ropivacaine for Pain Relief After Spine Surgery","status":"COMPLETED","sponsor":"Aristotle University Of Thessaloniki","startDate":"2020-05-10","conditions":"Analgesia, Pain, Postoperative, Spinal Stenosis","enrollment":72},{"nctId":"NCT04394130","phase":"NA","title":"Analgesic Efficacy of Continuous Infusion of Local Anaesthetic Versus Single-shot Injection Interscalene Block","status":"COMPLETED","sponsor":"Eric Albrecht","startDate":"2020-05-12","conditions":"Analgesia","enrollment":60},{"nctId":"NCT05172739","phase":"PHASE4","title":"Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC","status":"RECRUITING","sponsor":"University of Crete","startDate":"2021-10-01","conditions":"Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic","enrollment":70},{"nctId":"NCT02619799","phase":"PHASE2, PHASE3","title":"A Comparative Study of Intrathecal Magnesium Sulphate & Midazolam With Epidural Ropivacaine for Caesarean Patients","status":"COMPLETED","sponsor":"Rangaraya Medical College","startDate":"2015-01","conditions":"Postoperative Pain","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"recentPublications":[{"date":"2025","pmid":"40330998","title":"The Role of Periarticular Injections for Postoperative Pain after Total Knee Arthroplasty.","journal":"The archives of bone and joint surgery"},{"date":"2024 Aug 1","pmid":"39124765","title":"Efficacy and Safety of Magnesium Sulfate as an Adjunct to Ropivacaine Wound Infiltration in Thyroid Surgery: A Prospective, Double-Blind, Randomized Controlled Trial.","journal":"Journal of clinical medicine"},{"date":"2023 Mar","pmid":"37073187","title":"Comparison of Ropivacaine Plus Dexmedetomidine and Ropivacaine Plus Magnesium Sulfate Infiltration for Postoperative Analgesia in Patients Undergoing Lumbar Spine Surgeries.","journal":"Cureus"},{"date":"2020 Oct-Dec","pmid":"34349322","title":"Dexmedetomidine and Magnesium Sulfate as Adjuvant to 0.5% Ropivacaine in Supraclavicular Brachial Plexus Block: A Comparative Evaluation.","journal":"Anesthesia, essays and researches"},{"date":"2024 Apr","pmid":"33332200","title":"Comparison the effect of bupivacaine plus magnesium sulfate with ropivacaine plus magnesium sulfate infiltration on postoperative pain in patients undergoing lumbar laminectomy with general anesthesia.","journal":"British journal of neurosurgery"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"MgSO4 plus Ropivacaine","genericName":"MgSO4 plus Ropivacaine","companyName":"Hospital Universiti Sains Malaysia","companyId":"hospital-universiti-sains-malaysia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Magnesium sulfate enhances the local anesthetic effect of ropivacaine by potentiating neural blockade and reducing pain transmission. Used for Regional anesthesia and analgesia (peripheral nerve blocks, epidural anesthesia), Postoperative pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}