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Methylprednisolone or equivalent
Methylprednisolone or equivalent is a Glucocorticoid (corticosteroid) Small molecule drug developed by Sanofi. It is currently FDA-approved for Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis), Allergic reactions and asthma exacerbations, Adrenal insufficiency.
Methylprednisolone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
Methylprednisolone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Rheumatoid arthritis, Systemic lupus erythematosus, Polymyalgia rheumatica.
At a glance
| Generic name | Methylprednisolone or equivalent |
|---|---|
| Sponsor | Sanofi |
| Drug class | Glucocorticoid (corticosteroid) |
| Target | Glucocorticoid receptor (GR) |
| Modality | Small molecule |
| Therapeutic area | Immunology, Rheumatology, Endocrinology |
| Phase | FDA-approved |
Mechanism of action
Methylprednisolone acts as a potent immunosuppressant and anti-inflammatory agent by binding intracellular glucocorticoid receptors, which translocate to the nucleus and modulate gene expression. This leads to decreased production of inflammatory mediators (cytokines, chemokines, adhesion molecules) and reduced immune cell activation and proliferation. It is commonly used as a reference standard for corticosteroid potency comparisons.
Approved indications
- Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis)
- Allergic reactions and asthma exacerbations
- Adrenal insufficiency
- Cerebral edema
- Multiple sclerosis relapse
- Organ transplant rejection prophylaxis
Common side effects
- Hyperglycemia
- Hypertension
- Insomnia and mood changes
- Increased infection risk
- Osteoporosis (with chronic use)
- Gastrointestinal upset
- Cushingoid features (with chronic use)
Key clinical trials
- Short-term Steroid Therapy in Patients With P. Jirovecii Pneumonia Due to HIV / AIDS (NA)
- Ruxolitinib, Human Chorionic Gonadotropin (uhCG/EGF), and Dose De-escalated Corticosteroids (PHASE1, PHASE2)
- The Efficacy and Safety of Biologics (Belimumab/ Telitacicept) Induction Therapy in Proliferative Lupus Nephritis Patients for 6 Months Compared With Mycophenolate Mofetil Treatment (PHASE2)
- Daratumumab in STK11 Mutated NSCLC (PHASE2)
- A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants (PHASE2)
- Vitamin C With Steroids for Gastrointestinal GVHD (EARLY_PHASE1)
- Autoantibody Reduction for Acute Exacerbations of Idiopathic Pulmonary Fibrosis (PHASE2)
- A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Methylprednisolone or equivalent CI brief — competitive landscape report
- Methylprednisolone or equivalent updates RSS · CI watch RSS
- Sanofi portfolio CI
Frequently asked questions about Methylprednisolone or equivalent
What is Methylprednisolone or equivalent?
How does Methylprednisolone or equivalent work?
What is Methylprednisolone or equivalent used for?
Who makes Methylprednisolone or equivalent?
What drug class is Methylprednisolone or equivalent in?
What development phase is Methylprednisolone or equivalent in?
What are the side effects of Methylprednisolone or equivalent?
What does Methylprednisolone or equivalent target?
Related
- Drug class: All Glucocorticoid (corticosteroid) drugs
- Target: All drugs targeting Glucocorticoid receptor (GR)
- Manufacturer: Sanofi — full pipeline
- Therapeutic area: All drugs in Immunology, Rheumatology, Endocrinology
- Indication: Drugs for Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis)
- Indication: Drugs for Allergic reactions and asthma exacerbations
- Indication: Drugs for Adrenal insufficiency
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing