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Methylprednisolone 4 milligram Tab
Methylprednisolone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.
Methylprednisolone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Inflammatory and autoimmune disorders (rheumatoid arthritis, systemic lupus erythematosus, polymyalgia rheumatica), Allergic reactions and asthma, Adrenocortical insufficiency.
At a glance
| Generic name | Methylprednisolone 4 milligram Tab |
|---|---|
| Sponsor | F. Johannes Plate |
| Drug class | Glucocorticoid |
| Target | Glucocorticoid receptor (GR) |
| Modality | Small molecule |
| Therapeutic area | Immunology, Rheumatology, Endocrinology |
| Phase | FDA-approved |
Mechanism of action
Methylprednisolone acts as a glucocorticoid receptor agonist, translocating to the nucleus and modulating gene expression to decrease production of inflammatory mediators such as TNF-α, IL-1, and IL-6. It also suppresses T-cell activation and proliferation, reduces vascular permeability, and stabilizes lysosomal membranes, collectively producing broad anti-inflammatory and immunosuppressive effects.
Approved indications
- Inflammatory and autoimmune disorders (rheumatoid arthritis, systemic lupus erythematosus, polymyalgia rheumatica)
- Allergic reactions and asthma
- Adrenocortical insufficiency
- Cerebral edema
- Multiple sclerosis exacerbations
Common side effects
- Insomnia
- Increased appetite
- Nervousness or anxiety
- Headache
- Dizziness
- Nausea
- Immunosuppression (increased infection risk)
- Osteoporosis (with chronic use)
- Hyperglycemia
- Hypertension
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Methylprednisolone 4 milligram Tab CI brief — competitive landscape report
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- F. Johannes Plate portfolio CI