{"id":"methylprednisolone-4-milligram-tab","safety":{"commonSideEffects":[{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Increased appetite"},{"rate":null,"effect":"Nervousness or anxiety"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Immunosuppression (increased infection risk)"},{"rate":null,"effect":"Osteoporosis (with chronic use)"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hypertension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methylprednisolone acts as a glucocorticoid receptor agonist, translocating to the nucleus and modulating gene expression to decrease production of inflammatory mediators such as TNF-α, IL-1, and IL-6. It also suppresses T-cell activation and proliferation, reduces vascular permeability, and stabilizes lysosomal membranes, collectively producing broad anti-inflammatory and immunosuppressive effects.","oneSentence":"Methylprednisolone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:58.559Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and autoimmune disorders (rheumatoid arthritis, systemic lupus erythematosus, polymyalgia rheumatica)"},{"name":"Allergic reactions and asthma"},{"name":"Adrenocortical insufficiency"},{"name":"Cerebral edema"},{"name":"Multiple sclerosis exacerbations"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Methylprednisolone 4 milligram Tab","genericName":"Methylprednisolone 4 milligram Tab","companyName":"F. Johannes Plate","companyId":"f-johannes-plate","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methylprednisolone is a synthetic glucocorticoid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Inflammatory and autoimmune disorders (rheumatoid arthritis, systemic lupus erythematosus, polymyalgia rheumatica), Allergic reactions and asthma, Adrenocortical insufficiency.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}