Last reviewed · How we verify

Crodimyl (METHYLCHROMONE)

Phase 2 active Small molecule ✓ Verified May 2026 Quality 15/100

Crodimyl (generic name: METHYLCHROMONE) is a drug. It is currently in Phase 2 development for Angina pectoris.

Crodimyl works by modulating the activity of a specific cellular pathway to improve blood flow to the heart.

Crodimyl is a small molecule with the chemical name 3-METHYL-4(H)-CHROMEN-4-ONE. It is also known by other names, including Methylchromone, Metilcromona, NSC-76095, and Tricromyl.

Likelihood of approval
13.3% vs 15.3% industry baseline
If approved by FDA: likely 2031–2034
Steps remaining: Phase 3 → NDA/BLA submission
Confidence: Medium
Why this estimate
  • Baseline phase 2 → approval rate +15.3pp
    Industry-wide phase 2 drugs reach approval ~15.3% of the time (BIO/Informa 2023 industry benchmark across all therapeutic areas).
  • Cardiovascular Phase 3 risk -2.0pp
    Modern cardiovascular outcome trials are large + long; many fail to beat aggressive standard-of-care.
Predicted approval windows by jurisdiction (conditional on FDA approval)
Regulator Country Likely year Lag vs FDA
FDA US 2031–2034
EMA EU 2032–2035 +0.7 yr
MHRA GB 2032–2035 +0.7 yr
Health Canada CA 2032–2036 +0.9 yr
TGA AU 2032–2036 +1.2 yr
PMDA JP 2032–2036 +1.5 yr
NMPA CN 2033–2037 +2.3 yr
MFDS KR 2032–2036 +1.4 yr
CDSCO IN 2032–2037 +1.8 yr
ANVISA BR 2033–2037 +2.3 yr

Hover any row for the lag rationale. Lag estimates are reduced when the drug has FDA Breakthrough or EMA PRIME designation (sponsors file globally in parallel).

Estimate based on the BIO/Informa industry phase transition rates plus per-drug modifiers for therapeutic area, sponsor type, FDA designations, mechanism, and trial design. Per-jurisdiction lags from Tufts CSDD international approval studies. Not investment, clinical or regulatory advice. Methodology: /methodology#likelihood.

At a glance

Generic nameMETHYLCHROMONE
ModalitySmall molecule
Therapeutic areaCardiovascular
PhasePhase 2

Mechanism of action

Imagine your heart as a muscle that needs oxygen to function properly. Crodimyl helps to improve the delivery of oxygen to the heart muscle by affecting the way blood vessels relax and constrict. This allows for better blood flow and reduces the risk of chest pain.

Approved indications

Common side effects

No common side effects on file.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Frequently asked questions about Crodimyl

What is Crodimyl?

Crodimyl (METHYLCHROMONE) is a Small molecule drug, indicated for Angina pectoris.

How does Crodimyl work?

Crodimyl works by modulating the activity of a specific cellular pathway to improve blood flow to the heart.

What is Crodimyl used for?

Crodimyl is indicated for Angina pectoris.

What is the generic name of Crodimyl?

METHYLCHROMONE is the generic (nonproprietary) name of Crodimyl.

What development phase is Crodimyl in?

Crodimyl is in Phase 2.

Related

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing