{"id":"methylchromone","rwe":[{"pmid":"41613224","year":"2026","title":"Chemical reactivity of 2-methylchromone with some nitrogen-based nucleophiles: reactions, DFT analysis, anticancer activity and molecular docking studies.","finding":"","journal":"RSC advances","studyType":"Clinical Study"},{"pmid":"40754376","year":"2025","title":"New tetrahydroanthraquinones and γ-butenolides from the fungus Auxarthron umbrinum DSM3193.","finding":"","journal":"Chinese journal of natural medicines","studyType":"Clinical Study"},{"pmid":"39938655","year":"2025","title":"Four pairs of meroterpenoid enantiomers with coumarin- and chromone-monoterpene skeletons from Gerbera piloselloides and their bioactive activities.","finding":"","journal":"Fitoterapia","studyType":"Clinical Study"},{"pmid":"39888361","year":"2025","title":"Molecular mechanisms of phytoconstituents from selected Egyptian plants against non-small cell lung cancer using integrated in vitro network pharmacology and molecular docking approach.","finding":"","journal":"Naunyn-Schmiedeberg's archives of pharmacology","studyType":"Clinical Study"},{"pmid":"39065605","year":"2024","title":"New Members of the Centrapalus Coumarin and Pauciflorin Series from Centrapalus pauciflorus.","finding":"","journal":"Pharmaceutics","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Angina pectoris","category":"indication"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"crodimyl","offLabel":[],"synonyms":["methylchromone","tricromyl","crodimyl","cromonalgina","diacromone","spasmocromona"],"timeline":[],"approvals":[],"brandName":"Crodimyl","ecosystem":[{"indication":"Angina pectoris","otherDrugs":[{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"},{"name":"atenolol","slug":"atenolol","company":"Alvogen Ipco Sarl"},{"name":"atorvastatin","slug":"atorvastatin","company":"Pfizer"},{"name":"bepridil","slug":"bepridil","company":""}],"globalPrevalence":112000000}],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your heart as a muscle that needs oxygen to function properly. Crodimyl helps to improve the delivery of oxygen to the heart muscle by affecting the way blood vessels relax and constrict. This allows for better blood flow and reduces the risk of chest pain.","oneSentence":"Crodimyl works by modulating the activity of a specific cellular pathway to improve blood flow to the heart.","technicalDetail":"The exact mechanism of action of Crodimyl is not well understood, but it is believed to involve the modulation of calcium channels and the subsequent relaxation of vascular smooth muscle."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3632","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METHYLCHROMONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:02:18.703582","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:50:13.090602+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"genericName":"methylchromone","indications":{"approved":[{"name":"Angina pectoris","source":"DrugCentral","snomedId":194828000,"regulator":"FDA","usPrevalence":null,"globalPrevalence":112000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"KJ0091KAAH","CHEBI":"CHEBI:134790","INN_ID":"897","UMLSCUI":"C1881805","ChEMBL_ID":"CHEMBL2105215","PUBCHEM_CID":"66569"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":85,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan 26","pmid":"41613224","title":"Chemical reactivity of 2-methylchromone with some nitrogen-based nucleophiles: reactions, DFT analysis, anticancer activity and molecular docking studies.","journal":"RSC advances"},{"date":"2025 Aug","pmid":"40754376","title":"New tetrahydroanthraquinones and γ-butenolides from the fungus Auxarthron umbrinum DSM3193.","journal":"Chinese journal of natural medicines"},{"date":"2025 Apr","pmid":"39938655","title":"Four pairs of meroterpenoid enantiomers with coumarin- and chromone-monoterpene skeletons from Gerbera piloselloides and their bioactive activities.","journal":"Fitoterapia"},{"date":"2025 Jul","pmid":"39888361","title":"Molecular mechanisms of phytoconstituents from selected Egyptian plants against non-small cell lung cancer using integrated in vitro network pharmacology and molecular docking approach.","journal":"Naunyn-Schmiedeberg's archives of pharmacology"},{"date":"2024 Jul 6","pmid":"39065605","title":"New Members of the Centrapalus Coumarin and Pauciflorin Series from Centrapalus pauciflorus.","journal":"Pharmaceutics"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Crodimyl is a small molecule with the chemical name 3-METHYL-4(H)-CHROMEN-4-ONE. It is also known by other names, including Methylchromone, Metilcromona, NSC-76095, and Tricromyl.","enrichmentLevel":5,"visitCount":1,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:50:13.090602+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}