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Metamizole and Acetaminophen iv
Metamizole and Acetaminophen iv is a Non-opioid analgesic and antipyretic combination Small molecule drug developed by Hospital General Universitario Elche. It is currently in Phase 3 development for Moderate acute pain, Fever reduction. Also known as: Analgesia iv.
Metamizole and acetaminophen are non-opioid analgesics and antipyretics that inhibit prostaglandin synthesis and modulate pain perception to reduce fever and pain.
Metamizole and acetaminophen are non-opioid analgesics and antipyretics that inhibit prostaglandin synthesis and modulate pain perception to reduce fever and pain. Used for Moderate acute pain, Fever reduction.
At a glance
| Generic name | Metamizole and Acetaminophen iv |
|---|---|
| Also known as | Analgesia iv |
| Sponsor | Hospital General Universitario Elche |
| Drug class | Non-opioid analgesic and antipyretic combination |
| Target | Cyclooxygenase (COX) enzymes; central pain and temperature regulation pathways |
| Modality | Small molecule |
| Therapeutic area | Pain Management, Fever Management |
| Phase | Phase 3 |
Mechanism of action
Metamizole (dipyrone) is a pyrazolone derivative that inhibits cyclooxygenase enzymes and reduces prostaglandin production, providing analgesic and antipyretic effects. Acetaminophen (paracetamol) works through similar mechanisms, primarily affecting central pain perception and thermoregulation. The combination provides enhanced analgesic and antipyretic efficacy through complementary mechanisms.
Approved indications
- Moderate acute pain
- Fever reduction
Common side effects
- Gastrointestinal upset
- Hepatotoxicity (acetaminophen)
- Agranulocytosis (metamizole, rare)
- Allergic reactions
Key clinical trials
- Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery (PHASE4)
- Opioid-free Anesthesia as an Alternative to General Anesthesia in Abdominal Surgery (NA)
- Comparing Protocols for Analgesia Following Elective Cesarean Section (PHASE4)
- Ultrasound-Guided Thoracic Paravertebral Blocks in Patients Undergoing Reduction Mammoplasty
- Analgesia iv vs Epidural Analgesia vs Port-sites Infiltration After Laparoscopic Sleeve Gastrectomy (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Metamizole and Acetaminophen iv CI brief — competitive landscape report
- Metamizole and Acetaminophen iv updates RSS · CI watch RSS
- Hospital General Universitario Elche portfolio CI
Frequently asked questions about Metamizole and Acetaminophen iv
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Related
- Drug class: All Non-opioid analgesic and antipyretic combination drugs
- Target: All drugs targeting Cyclooxygenase (COX) enzymes; central pain and temperature regulation pathways
- Manufacturer: Hospital General Universitario Elche — full pipeline
- Therapeutic area: All drugs in Pain Management, Fever Management
- Indication: Drugs for Moderate acute pain
- Indication: Drugs for Fever reduction
- Also known as: Analgesia iv
- Compare: Metamizole and Acetaminophen iv vs similar drugs
- Pricing: Metamizole and Acetaminophen iv cost, discount & access