{"id":"metamizole-and-acetaminophen-iv","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Hepatotoxicity (acetaminophen)"},{"rate":null,"effect":"Agranulocytosis (metamizole, rare)"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL461522","moleculeType":"Small molecule","molecularWeight":"311.36"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metamizole (dipyrone) is a pyrazolone derivative that inhibits cyclooxygenase enzymes and reduces prostaglandin production, providing analgesic and antipyretic effects. Acetaminophen (paracetamol) works through similar mechanisms, primarily affecting central pain perception and thermoregulation. The combination provides enhanced analgesic and antipyretic efficacy through complementary mechanisms.","oneSentence":"Metamizole and acetaminophen are non-opioid analgesics and antipyretics that inhibit prostaglandin synthesis and modulate pain perception to reduce fever and pain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:20:56.241Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate acute pain"},{"name":"Fever reduction"}]},"trialDetails":[{"nctId":"NCT06878014","phase":"PHASE4","title":"Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery","status":"RECRUITING","sponsor":"Medical University of Silesia","startDate":"2025-03-04","conditions":"Analgesics, Opioid, Anesthesia, Spinal, Total Hip Replacement","enrollment":120},{"nctId":"NCT06380244","phase":"NA","title":"Opioid-free Anesthesia as an Alternative to General Anesthesia in Abdominal Surgery","status":"RECRUITING","sponsor":"Jagiellonian University","startDate":"2024-03-10","conditions":"Analgesics, Opioid, Anesthesia, Endotracheal, Anesthesia, General","enrollment":100},{"nctId":"NCT03622489","phase":"PHASE4","title":"Comparing Protocols for Analgesia Following Elective Cesarean Section","status":"UNKNOWN","sponsor":"Wolfson Medical Center","startDate":"2017-03-01","conditions":"Postoperative Pain, Post-Cesarean Section","enrollment":120},{"nctId":"NCT02671851","phase":"","title":"Ultrasound-Guided Thoracic Paravertebral Blocks in Patients Undergoing Reduction Mammoplasty","status":"COMPLETED","sponsor":"Istanbul University","startDate":"2014-01","conditions":"Pain, Postoperative","enrollment":64},{"nctId":"NCT02662660","phase":"PHASE3","title":"Analgesia iv vs Epidural Analgesia vs Port-sites Infiltration After Laparoscopic Sleeve Gastrectomy","status":"COMPLETED","sponsor":"Hospital General Universitario Elche","startDate":"2012-01","conditions":"Postoperative Pain","enrollment":147}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Analgesia iv"],"phase":"phase_3","status":"active","brandName":"Metamizole and Acetaminophen iv","genericName":"Metamizole and Acetaminophen iv","companyName":"Hospital General Universitario Elche","companyId":"hospital-general-universitario-elche","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metamizole and acetaminophen are non-opioid analgesics and antipyretics that inhibit prostaglandin synthesis and modulate pain perception to reduce fever and pain. Used for Moderate acute pain, Fever reduction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}