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Metamizol iv
Metamizol is a non-selective cyclooxygenase (COX) inhibitor that reduces prostaglandin synthesis to provide analgesic, antipyretic, and anti-inflammatory effects.
Metamizol is a non-selective cyclooxygenase (COX) inhibitor that reduces prostaglandin synthesis to provide analgesic, antipyretic, and anti-inflammatory effects. Used for Acute pain management (postoperative, trauma, or other acute pain conditions), Fever reduction.
At a glance
| Generic name | Metamizol iv |
|---|---|
| Also known as | Nolotil |
| Sponsor | Hospital General Universitario Elche |
| Drug class | Non-selective COX inhibitor / NSAID |
| Target | Cyclooxygenase (COX-1 and COX-2) |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Fever |
| Phase | Phase 3 |
Mechanism of action
Metamizol (dipyrone) inhibits COX enzymes, thereby decreasing prostaglandin production, which mediates pain, fever, and inflammation. It is a prodrug that is rapidly metabolized to active metabolites including 4-methylaminoantipyrine (MAA), which exerts the primary pharmacological effects. The drug has a rapid onset and is commonly used for acute pain and fever management.
Approved indications
- Acute pain management (postoperative, trauma, or other acute pain conditions)
- Fever reduction
Common side effects
- Agranulocytosis
- Anaphylaxis / hypersensitivity reactions
- Gastrointestinal upset
- Dizziness
- Rash
Key clinical trials
- Effects of Red and Infrared Photobiomodulation in Rhinoplasty at a Single Centre (NA)
- Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery (PHASE4)
- Antipyretic Treatment for Intrapartum Fever: Dipyrone vs Acetaminophen (RCT) (PHASE4)
- Opioid-free Anesthesia as an Alternative to General Anesthesia in Abdominal Surgery (NA)
- Opioid Based Analgesia vs Non-opioid Analgesia for Oocyte Retrieval Procedure (NA)
- Ketofol Versus Propofol for Sedation in Cholangiopancreatography for ASA III and ASA IV Patients. (NA)
- Evaluation of the Roll of IV Fluids in the Treatment of Renal Colic (PHASE4)
- Comparing Protocols for Analgesia Following Elective Cesarean Section (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Metamizol iv CI brief — competitive landscape report
- Metamizol iv updates RSS · CI watch RSS
- Hospital General Universitario Elche portfolio CI