{"id":"metamizol-iv","safety":{"commonSideEffects":[{"rate":null,"effect":"Agranulocytosis"},{"rate":null,"effect":"Anaphylaxis / hypersensitivity reactions"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metamizol (dipyrone) inhibits COX enzymes, thereby decreasing prostaglandin production, which mediates pain, fever, and inflammation. It is a prodrug that is rapidly metabolized to active metabolites including 4-methylaminoantipyrine (MAA), which exerts the primary pharmacological effects. The drug has a rapid onset and is commonly used for acute pain and fever management.","oneSentence":"Metamizol is a non-selective cyclooxygenase (COX) inhibitor that reduces prostaglandin synthesis to provide analgesic, antipyretic, and anti-inflammatory effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:20:53.182Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management (postoperative, trauma, or other acute pain conditions)"},{"name":"Fever reduction"}]},"trialDetails":[{"nctId":"NCT07033039","phase":"NA","title":"Effects of Red and Infrared Photobiomodulation in Rhinoplasty at a Single Centre","status":"RECRUITING","sponsor":"University of Nove de Julho","startDate":"2026-01-30","conditions":"Rhinoplasty, Edema","enrollment":60},{"nctId":"NCT06878014","phase":"PHASE4","title":"Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement 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reduces prostaglandin synthesis to provide analgesic, antipyretic, and anti-inflammatory effects. Used for Acute pain management (postoperative, trauma, or other acute pain conditions), Fever reduction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}