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Melaleuca Alternifolia Oil
Melaleuca alternifolia oil exerts antimicrobial and anti-inflammatory effects through its volatile terpene components, primarily terpineol and cineole, which disrupt microbial cell membranes and reduce inflammatory mediators.
Melaleuca alternifolia oil exerts antimicrobial and anti-inflammatory effects through its volatile terpene components, primarily terpineol and cineole, which disrupt microbial cell membranes and reduce inflammatory mediators. Used for Topical antimicrobial and antifungal treatment, Acne vulgaris, Fungal skin infections.
At a glance
| Generic name | Melaleuca Alternifolia Oil |
|---|---|
| Sponsor | Ain Shams University |
| Drug class | Herbal/botanical extract |
| Modality | Small molecule |
| Therapeutic area | Dermatology, Antimicrobial, Anti-inflammatory |
| Phase | FDA-approved |
Mechanism of action
The essential oil from the tea tree plant contains bioactive monoterpenes that penetrate bacterial and fungal cell walls, causing leakage and cell death. Additionally, the oil modulates immune responses by reducing pro-inflammatory cytokines and oxidative stress, contributing to its therapeutic effects in topical infections and inflammatory skin conditions.
Approved indications
- Topical bacterial and fungal skin infections
- Acne vulgaris
- Fungal nail infections (onychomycosis)
- Wound healing and minor cuts
Common side effects
- Contact dermatitis / skin irritation
- Allergic reaction
- Sensitization with repeated use
Key clinical trials
- Evaluation Through Innovative Examinations of Intestinal Dysbiosis Status in Patients Diagnosed With Cardiovascular Diseases and Evaluation of the Efficacy of Natural and Probiotic Extracts in the Non-pharmacological Approach to Improving Intestinal Dysbiosis Status. (NA)
- Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar Extraction (NA)
- Healing Effect of Tea Tree Oil on Burn (EARLY_PHASE1)
- Effectiveness of Low Level Light Therapy and Intense Pulse Light on Mite Count as Adjuntive Therapies in Demodex Blepharitis Using Artificial Intelligent Program (Ai-Demodex) (NA)
- Effects of Aromatherapy on Anxiety and Pain During Dental Treatment in Adults (NA)
- Comparing Efficacy of Tea Tree Oil Versus Topical Azithromycin in Treating Dry Eye (PHASE1, PHASE2)
- Clinical and Microbiological Evaluation Of The Efficacy Of Herbal Mouthwashes in Gingivitis (PHASE4)
- The Effect of an Antioxidant Gel Compared to Chlorhexidine Gel During the Soft Tissue Healing Process: A Randomized Controlled Clinical Trial (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Melaleuca Alternifolia Oil CI brief — competitive landscape report
- Melaleuca Alternifolia Oil updates RSS · CI watch RSS
- Ain Shams University portfolio CI