{"id":"melaleuca-alternifolia-oil","safety":{"commonSideEffects":[{"rate":null,"effect":"Contact dermatitis / skin irritation"},{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Sensitization with repeated use"}]},"_chembl":{"chemblId":"CHEMBL2107910","moleculeType":"Unknown"},"_dailymed":{"setId":"3930ab37-9d6a-424e-9eac-a55283afc303","title":"SHAILEE TEA TREE BODY WASH (THYME OIL,MELALEUCA ALTERNIFOLIA,OREGANO OIL,LAVENDER OI,UNDECYLENIC ACIDL) LIQUID [FOSHAN SUGAR MAX COSMETICS CO.,LTD]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The essential oil from the tea tree plant contains bioactive monoterpenes that penetrate bacterial and fungal cell walls, causing leakage and cell death. Additionally, the oil modulates immune responses by reducing pro-inflammatory cytokines and oxidative stress, contributing to its therapeutic effects in topical infections and inflammatory skin conditions.","oneSentence":"Melaleuca alternifolia oil exerts antimicrobial and anti-inflammatory effects through its volatile terpene components, primarily terpineol and cineole, which disrupt microbial cell membranes and reduce inflammatory mediators.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T04:17:56.496Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical bacterial and fungal skin infections"},{"name":"Acne vulgaris"},{"name":"Fungal nail infections (onychomycosis)"},{"name":"Wound healing and minor cuts"}]},"trialDetails":[{"nctId":"NCT07429227","phase":"NA","title":"Evaluation Through Innovative Examinations of Intestinal Dysbiosis Status in Patients Diagnosed With Cardiovascular Diseases and Evaluation of the Efficacy of Natural and Probiotic Extracts in the Non-pharmacological Approach to Improving Intestinal Dysbiosis Status.","status":"RECRUITING","sponsor":"Casa di Cura Dott. Pederzoli","startDate":"2026-03","conditions":"Acute Coronary Syndromes (ACS)","enrollment":15},{"nctId":"NCT07180498","phase":"NA","title":"Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar Extraction","status":"RECRUITING","sponsor":"Harran University","startDate":"2025-04-15","conditions":"Postoperative Pain, Postoperative Complications, Trismus","enrollment":54},{"nctId":"NCT07149844","phase":"EARLY_PHASE1","title":"Healing Effect of Tea Tree Oil on Burn","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2021-07-02","conditions":"Burn","enrollment":30},{"nctId":"NCT07169461","phase":"NA","title":"Effectiveness of Low Level Light Therapy and Intense Pulse Light on Mite Count as Adjuntive Therapies in Demodex Blepharitis Using Artificial Intelligent Program (Ai-Demodex)","status":"ENROLLING_BY_INVITATION","sponsor":"Chulalongkorn University","startDate":"2025-01-16","conditions":"Demodex Blepharitis, Meibomian Gland Dysfunction (MGD)","enrollment":88},{"nctId":"NCT06347679","phase":"NA","title":"Effects of Aromatherapy on Anxiety and Pain During Dental Treatment in Adults","status":"RECRUITING","sponsor":"Sichuan University","startDate":"2024-05-01","conditions":"Dental Anxiety","enrollment":120},{"nctId":"NCT06921525","phase":"PHASE1, PHASE2","title":"Comparing Efficacy of Tea Tree Oil Versus Topical Azithromycin in Treating Dry Eye","status":"NOT_YET_RECRUITING","sponsor":"Ehab Mohamed Elsayed Mohamed Saad","startDate":"2025-04-01","conditions":"Dry Eye","enrollment":44},{"nctId":"NCT06904742","phase":"PHASE4","title":"Clinical and Microbiological Evaluation Of The Efficacy Of Herbal Mouthwashes in Gingivitis","status":"COMPLETED","sponsor":"Altinbas University","startDate":"2024-02-12","conditions":"Periodontal Diseases","enrollment":52},{"nctId":"NCT06894667","phase":"PHASE4","title":"The Effect of an Antioxidant Gel Compared to Chlorhexidine Gel During the Soft Tissue Healing Process: A Randomized Controlled Clinical Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"Kuwait University","startDate":"2024-11-01","conditions":"Periodontal Diseases","enrollment":40},{"nctId":"NCT05367414","phase":"NA","title":"Aromatherapy Massage for Itching Management in Liver Diseases","status":"COMPLETED","sponsor":"Amine Terzi","startDate":"2020-02-13","conditions":"Aromatherapy, Massage, Liver Diseases","enrollment":36},{"nctId":"NCT06711263","phase":"NA","title":"Role of Herbal Based Mouthwashes in Plaque Control","status":"NOT_YET_RECRUITING","sponsor":"Ajman University","startDate":"2024-12-20","conditions":"Plaque Induced Gingival Disease","enrollment":80},{"nctId":"NCT03816735","phase":"NA","title":"Laser vs Hyaluronic Acid for GSM in Breast Cancer","status":"UNKNOWN","sponsor":"Medical University of Graz","startDate":"2019-01-24","conditions":"Urogenital Disease","enrollment":50},{"nctId":"NCT05990712","phase":"PHASE4","title":"The Effect of a Pre-cataract Surgical Ocular Hygiene Regime on Microbial Load, Tear Osmolarity, Dry Eye, and Inflammatory Markers","status":"UNKNOWN","sponsor":"Uptown Eye Specialists","startDate":"2023-09-01","conditions":"Dry Eye, Dry Eye Syndromes, Cataract","enrollment":68},{"nctId":"NCT05467631","phase":"NA","title":"Topical Phytoterpenes for Plantar Fasciitis","status":"COMPLETED","sponsor":"Center for Biomedical Research, Inc.","startDate":"2019-01-15","conditions":"Plantar Fasciitis","enrollment":42},{"nctId":"NCT05899699","phase":"PHASE2","title":"Effect of New Topical Preparation for Treatment of Acne Vulgaris","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2023-06-05","conditions":"Acne Vulgaris","enrollment":20},{"nctId":"NCT05803031","phase":"NA","title":"Efficacy of Locally Delivered Tea Tree Oil Gel as an Adjunct to Non-Surgical Periodontal Management","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2022-11-01","conditions":"Periodontal Pocket","enrollment":22},{"nctId":"NCT05456438","phase":"NA","title":"Effect of Tea Tree Oil and Coconut Oil on Nipple Crack Formation","status":"COMPLETED","sponsor":"Hitit University","startDate":"2021-02-14","conditions":"Nipple Infection","enrollment":90},{"nctId":"NCT04836364","phase":"","title":"Skincare Products and Environmental Health","status":"UNKNOWN","sponsor":"Nutraceuticals Research Institute","startDate":"2019-01-14","conditions":"Gynecomastia, Endocrine System Diseases","enrollment":2000},{"nctId":"NCT04769271","phase":"PHASE2","title":"Intra-pocket Application of Tea Tree Oil Gel in the Treatment of Stage-2 Periodontitis","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2019-11-10","conditions":"Periodontitis","enrollment":30},{"nctId":"NCT04678531","phase":"PHASE4","title":"TTO Swabs Versus Baby Shampoo in Patients With Seborrehic Blepharitis","status":"COMPLETED","sponsor":"Istanbul University - Cerrahpasa","startDate":"2018-11-12","conditions":"Seborrheic Blepharitis","enrollment":49},{"nctId":"NCT04558697","phase":"PHASE4","title":"Use of Vagitories Based on St. John's Wort, Tea Tree Oil and Shepherd's Purse in the Treatment of Vaginal Inflammation","status":"COMPLETED","sponsor":"University of Sarajevo","startDate":"2019-03-21","conditions":"Non Specific Vaginitis","enrollment":210},{"nctId":"NCT04451122","phase":"NA","title":"Treatment of Ocular Demodicosis by Cleansing the Eyelid Margins Combined With Tea Tree Oil Ointment","status":"UNKNOWN","sponsor":"Wenzhou Medical University","startDate":"2019-06-01","conditions":"Mite-Borne","enrollment":60},{"nctId":"NCT04204954","phase":"PHASE2, PHASE3","title":"Evaluation of Treatment Option for Demodicosis in Patients Undergoing Cataract Surgery","status":"COMPLETED","sponsor":"Hospital de La Luz","startDate":"2019-05-06","conditions":"Demodex Infestation, Demodicosis, Cataract","enrollment":160},{"nctId":"NCT03422146","phase":"NA","title":"Antimicrobial and Clinical Efficacy of Cliradex® as Compared With I-Lid'n Lash® Hygiene in Treating Blepharitis","status":"UNKNOWN","sponsor":"Ottawa Hospital Research Institute","startDate":"2017-02-19","conditions":"Blepharitis, Meibomian Gland Dysfunction","enrollment":40},{"nctId":"NCT03287011","phase":"NA","title":"Efficacy of a Plaque Disclosing Toothpaste on Home Oral Hygiene Procedures","status":"UNKNOWN","sponsor":"Segi University","startDate":"2017-09-11","conditions":"Chronic Gingivitis, Plaque Induced","enrollment":50},{"nctId":"NCT01647217","phase":"PHASE1","title":"Demodex Blepharitis Treatment Study","status":"COMPLETED","sponsor":"BioTissue Holdings, Inc","startDate":"2014-02","conditions":"Chronic Blepharitis","enrollment":17},{"nctId":"NCT02695901","phase":"PHASE4","title":"Effect of Different Mouthrinses in Plaque Formation","status":"UNKNOWN","sponsor":"Universidade Federal de Santa Maria","startDate":"2016-03","conditions":"Dental Plaque","enrollment":59},{"nctId":"NCT01657110","phase":"PHASE2","title":"Pilot Study to Evaluate Tea Tree Oil Gel for Facial Acne","status":"COMPLETED","sponsor":"The University of Western Australia","startDate":"2012-12","conditions":"Acne","enrollment":18},{"nctId":"NCT01930565","phase":"NA","title":"Effectiveness and Safety of New Botanical Component-LFCO- Compared With Existing TTO in Clinical Study","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2013-01","conditions":"Acne Vulgaris","enrollment":34},{"nctId":"NCT01929187","phase":"NA","title":"A Randomized Study to Evaluate the Efficacy of Herbal Ingredients Combined With a Carrier System (Phytonail) Compared With Amorolfine 5% Nail Lacquer (Loceryl) in the Treatment of Toenail Onychomycosis","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2013-02","conditions":"Onycomycosis","enrollment":72},{"nctId":"NCT01684371","phase":"","title":"The Effects of Elmore Oil on Patients With Osteoarthritis","status":"COMPLETED","sponsor":"Elmore Oil Company Pty Ltd","startDate":"2008-11","conditions":"Degenerative Arthritis, Inflammation","enrollment":60},{"nctId":"NCT01214395","phase":"PHASE2","title":"Nasal Tea Tree Oil for the Prevention of Infections in PD Patients","status":"COMPLETED","sponsor":"PathWest Laboratory Medicine WA","startDate":"2010-06","conditions":"End Stage Renal Failure on Dialysis","enrollment":5},{"nctId":"NCT01073150","phase":"PHASE2","title":"Tea Tree Oil in the Treatment of Chronic Blepharitis","status":"COMPLETED","sponsor":"Federal University of São Paulo","startDate":"2009-04","conditions":"Blepharitis","enrollment":34}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":51,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Melaleuca Alternifolia Oil","genericName":"Melaleuca Alternifolia Oil","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Melaleuca alternifolia oil exerts antimicrobial and anti-inflammatory effects through its volatile terpene components, primarily terpineol and cineole, which disrupt microbial cell membranes and reduce inflammatory mediators. Used for Topical antimicrobial and antifungal treatment, Acne vulgaris, Fungal skin infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}