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Marketed Cavity Protection Toothpaste
Cavity protection toothpaste prevents dental caries by delivering fluoride to remineralize tooth enamel and inhibit bacterial acid production.
Cavity protection toothpaste prevents dental caries by delivering fluoride to strengthen tooth enamel and inhibit bacterial acid production. Used for Cavity prevention in children and adults, Enamel remineralization.
At a glance
| Generic name | Marketed Cavity Protection Toothpaste |
|---|---|
| Sponsor | Procter and Gamble |
| Drug class | Fluoride-based remineralizing agent |
| Target | Tooth enamel hydroxyapatite; oral bacterial metabolism |
| Modality | Small molecule |
| Therapeutic area | Dental/Oral Health |
| Phase | FDA-approved |
Mechanism of action
Fluoride ions are incorporated into the hydroxyapatite crystal structure of tooth enamel, making it more resistant to demineralization by acids produced by oral bacteria. The fluoride also reduces the metabolic activity of cariogenic bacteria, decreasing their ability to produce acids that erode teeth. This dual mechanism strengthens enamel and reduces cavity formation.
Approved indications
- Cavity prevention in adults and children
- Enamel remineralization
Common side effects
- Dental fluorosis (with excessive ingestion, particularly in children)
- Mild gum irritation
Key clinical trials
- A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque Accumulation (NA)
- A Clinical Study Assessing the Effects of a Marketed Dentifrice on Tooth Sensitivity While Undergoing Tooth Bleaching (PHASE4)
- Determination of the Oral Irritation Potential of Two Alcohol-Free Rinses (NA)
- Determination of the Oral Irritation Potential of a Fluoride Rinse in Children (NA)
- A Study of Virtually Supervised Mouthwash and Interdental Brushes (PHASE4)
- A Twelve Week Study of Prototypes Mouth Rinses (PHASE4)
- A Study of Mouth Rinses in Type 1 and Type 2 Diabetic Participants (PHASE4)
- A Study of Virtually Supervised Mouth Rinses and Flossing (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Marketed Cavity Protection Toothpaste CI brief — competitive landscape report
- Marketed Cavity Protection Toothpaste updates RSS · CI watch RSS
- Procter and Gamble portfolio CI