{"id":"marketed-cavity-protection-toothpaste","safety":{"commonSideEffects":[{"rate":null,"effect":"Dental fluorosis (with excessive ingestion, particularly in children)"},{"rate":null,"effect":"Mild gum irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluoride ions are incorporated into the hydroxyapatite crystal structure of tooth enamel, making it more resistant to demineralization by acids produced by oral bacteria. The fluoride also reduces the metabolic activity of cariogenic bacteria, decreasing their ability to produce acids that erode teeth. This dual mechanism strengthens enamel and reduces cavity formation.","oneSentence":"Cavity protection toothpaste prevents dental caries by delivering fluoride to remineralize tooth enamel and inhibit bacterial acid production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:02.540Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cavity prevention in adults and children"},{"name":"Enamel remineralization"}]},"trialDetails":[{"nctId":"NCT07255040","phase":"NA","title":"A Clinical Study to Evaluate the Effectiveness of an Experimental Toothpaste in Improving Gum Health and Reducing Plaque Accumulation","status":"RECRUITING","sponsor":"HALEON","startDate":"2025-11-19","conditions":"Dental Plaque, Gingivitis","enrollment":300},{"nctId":"NCT06608368","phase":"PHASE4","title":"A Clinical Study Assessing the Effects of a Marketed Dentifrice on Tooth Sensitivity While Undergoing Tooth Bleaching","status":"COMPLETED","sponsor":"HALEON","startDate":"2024-10-07","conditions":"Dentin Sensitivity","enrollment":90},{"nctId":"NCT07160166","phase":"NA","title":"Determination of the Oral Irritation Potential of Two Alcohol-Free Rinses","status":"COMPLETED","sponsor":"Kenvue Brands LLC","startDate":"2025-07-11","conditions":"Oral Health","enrollment":169},{"nctId":"NCT06798441","phase":"NA","title":"Determination of the Oral Irritation Potential of a Fluoride Rinse in Children","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer and Personal Products Worldwide","startDate":"2025-01-20","conditions":"Healthy","enrollment":161},{"nctId":"NCT05756673","phase":"PHASE4","title":"A Study of Virtually Supervised Mouthwash and Interdental Brushes","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc. 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Used for Cavity prevention in children and adults, Enamel remineralization.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}