Last reviewed 2026-04-22 · How we verify

Mannitol Inhalation Kit

Mannitol inhalation acts as an osmotic agent that draws fluid into the airways to hydrate secretions and promote airway clearance.

Mannitol inhalation acts as an osmotic agent that draws fluid into the airways to hydrate secretions and promote airway clearance. Used for Cystic fibrosis (airway clearance), Bronchiectasis (airway clearance).

At a glance

Mechanism of action

When inhaled as a dry powder, mannitol particles absorb moisture from the airway mucosa, creating an osmotic gradient that increases airway surface liquid volume. This hydration of thick, viscous secretions makes them easier to expectorate and improves mucociliary clearance. The increased airway hydration may also trigger a cough reflex that aids in clearance of mucus and cellular debris.

Approved indications

• Cystic fibrosis (airway clearance)
• Bronchiectasis (airway clearance)

Common side effects

• Cough
• Throat irritation
• Bronchospasm
• Wheezing

Key clinical trials

• National Cohort of Subjects at Risk of Developing Rheumatoid Arthritis
• Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol (PHASE4)
• Measurement of Exhaled Nitric Oxide (NO) and Bronchial Provocation Test With Mannitol as a Predictor of Response to Inhaled Corticosteroids in Chronic Cough (NA)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

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