{"id":"mannitol-inhalation-kit","safety":{"commonSideEffects":[{"rate":null,"effect":"Cough"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Bronchospasm"},{"rate":null,"effect":"Wheezing"}]},"_chembl":{"chemblId":"CHEMBL4303619","moleculeType":"Small molecule","molecularWeight":"489.48"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"When inhaled as a dry powder, mannitol particles absorb moisture from the airway mucosa, creating an osmotic gradient that increases airway surface liquid volume. This hydration of thick, viscous secretions makes them easier to expectorate and improves mucociliary clearance. The increased airway hydration may also trigger a cough reflex that aids in clearance of mucus and cellular debris.","oneSentence":"Mannitol inhalation acts as an osmotic agent that draws fluid into the airways to hydrate secretions and promote airway clearance.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:53:51.416Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cystic fibrosis (airway clearance)"},{"name":"Bronchiectasis (airway clearance)"}]},"trialDetails":[{"nctId":"NCT06876064","phase":"","title":"National Cohort of Subjects at Risk of Developing Rheumatoid Arthritis","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Montpellier","startDate":"2025-10","conditions":"Rheumatoid Arthritis (RA)","enrollment":150},{"nctId":"NCT03105843","phase":"PHASE4","title":"Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol","status":"RECRUITING","sponsor":"Dr. Diane Lougheed","startDate":"2022-03-01","conditions":"Asthma, Cough, Cough Variant Asthma","enrollment":30},{"nctId":"NCT00916526","phase":"NA","title":"Measurement of Exhaled Nitric Oxide (NO) and Bronchial Provocation Test With Mannitol as a Predictor of Response to Inhaled Corticosteroids in Chronic Cough","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire de Saint Etienne","startDate":"2008-11","conditions":"Cough, Bronchial Hyperreactivity","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Mannitol Challenge Test"],"phase":"marketed","status":"active","brandName":"Mannitol Inhalation Kit","genericName":"Mannitol Inhalation Kit","companyName":"Dr. Diane Lougheed","companyId":"dr-diane-lougheed","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mannitol inhalation acts as an osmotic agent that draws fluid into the airways to hydrate secretions and promote airway clearance. Used for Cystic fibrosis (airway clearance), Bronchiectasis (airway clearance).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}