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maintenance of anaesthesia with propofol
maintenance of anaesthesia with propofol is a Sedative-hypnotic agent Small molecule drug developed by Centre Hospitalier Universitaire Dijon. It is currently FDA-approved for Maintenance of general anaesthesia during surgical procedures, Sedation in intensive care unit patients requiring mechanical ventilation.
Propofol is a sedative-hypnotic agent that enhances inhibitory GABAergic neurotransmission in the central nervous system to maintain general anaesthesia.
Propofol is a sedative-hypnotic agent that enhances inhibitory GABAergic neurotransmission in the central nervous system to maintain general anaesthesia. Used for Maintenance of general anaesthesia during surgical procedures, Sedation in intensive care unit patients requiring mechanical ventilation.
At a glance
| Generic name | maintenance of anaesthesia with propofol |
|---|---|
| Sponsor | Centre Hospitalier Universitaire Dijon |
| Drug class | Sedative-hypnotic agent |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anaesthesia |
| Phase | FDA-approved |
Mechanism of action
Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing the frequency and duration of chloride channel opening. This hyperpolarizes neuronal membranes, suppressing neuronal firing and producing sedation, hypnosis, and unconsciousness. It is commonly used for induction and maintenance of general anaesthesia in surgical and critical care settings.
Approved indications
- Maintenance of general anaesthesia during surgical procedures
- Sedation in intensive care unit patients requiring mechanical ventilation
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
- Apnea
- Propofol infusion syndrome (with prolonged use)
Key clinical trials
- Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery (NA)
- Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation (NA)
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery (NA)
- Deep Versus Moderate Neuromuscular Blocking (NA)
- Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio (PHASE4)
- Anesthesia-Masked Psilocybin Therapy for Major Depression (PHASE2)
- Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- maintenance of anaesthesia with propofol CI brief — competitive landscape report
- maintenance of anaesthesia with propofol updates RSS · CI watch RSS
- Centre Hospitalier Universitaire Dijon portfolio CI
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Related
- Drug class: All Sedative-hypnotic agent drugs
- Target: All drugs targeting GABA-A receptor
- Manufacturer: Centre Hospitalier Universitaire Dijon — full pipeline
- Therapeutic area: All drugs in Anaesthesia
- Indication: Drugs for Maintenance of general anaesthesia during surgical procedures
- Indication: Drugs for Sedation in intensive care unit patients requiring mechanical ventilation
- Compare: maintenance of anaesthesia with propofol vs similar drugs
- Pricing: maintenance of anaesthesia with propofol cost, discount & access