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Lubricating eyedrops containing hydroxypropyl-guar
Hydroxypropyl-guar forms a viscous gel layer on the ocular surface that lubricates and protects the cornea and conjunctiva.
Hydroxypropyl-guar forms a viscous gel layer on the ocular surface that lubricates and protects the cornea and conjunctiva. Used for Dry eye disease / keratoconjunctivitis sicca, Ocular surface lubrication and protection.
At a glance
| Generic name | Lubricating eyedrops containing hydroxypropyl-guar |
|---|---|
| Also known as | Systane lubricating eyedrops, ALCON |
| Sponsor | University of Zagreb |
| Drug class | Artificial tear / lubricating agent |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | FDA-approved |
Mechanism of action
Hydroxypropyl-guar is a natural polysaccharide derivative that increases tear film viscosity and provides prolonged ocular surface lubrication. It adheres to the corneal and conjunctival epithelium, reducing friction and protecting against further irritation. This mechanism is particularly effective for dry eye disease by maintaining moisture and reducing evaporation.
Approved indications
- Dry eye disease / keratoconjunctivitis sicca
- Ocular surface lubrication and protection
Common side effects
- Transient blurred vision
- Mild ocular irritation
- Conjunctival hyperemia
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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