{"id":"lubricating-eyedrops-containing-hydroxypropyl-guar","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient blurred vision"},{"rate":null,"effect":"Mild ocular irritation"},{"rate":null,"effect":"Conjunctival hyperemia"}]},"_chembl":{"chemblId":"CHEMBL2108446","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hydroxypropyl-guar is a natural polysaccharide derivative that increases tear film viscosity and provides prolonged ocular surface lubrication. It adheres to the corneal and conjunctival epithelium, reducing friction and protecting against further irritation. This mechanism is particularly effective for dry eye disease by maintaining moisture and reducing evaporation.","oneSentence":"Hydroxypropyl-guar forms a viscous gel layer on the ocular surface that lubricates and protects the cornea and conjunctiva.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:53:30.806Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease / keratoconjunctivitis sicca"},{"name":"Ocular surface lubrication and protection"}]},"trialDetails":[{"nctId":"NCT01268735","phase":"PHASE4","title":"The Effect of Ocular Lubricant Eyedrops on Lid Parallel Conjunctival Folds and Other Signs and Symptoms of Dry Eye","status":"COMPLETED","sponsor":"University of Zagreb","startDate":"2009-04","conditions":"Dry Eye Syndromes","enrollment":229}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Systane lubricating eyedrops, ALCON"],"phase":"marketed","status":"active","brandName":"Lubricating eyedrops containing hydroxypropyl-guar","genericName":"Lubricating eyedrops containing hydroxypropyl-guar","companyName":"University of Zagreb","companyId":"university-of-zagreb","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydroxypropyl-guar forms a viscous gel layer on the ocular surface that lubricates and protects the cornea and conjunctiva. Used for Dry eye disease / keratoconjunctivitis sicca, Ocular surface lubrication and protection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}