Last reviewed 2026-04-22 · How we verify

Loxoprofen sodium tablet

Loxoprofen sodium inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.

Loxoprofen sodium inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. Used for Mild to moderate pain, Inflammation and fever, Postoperative pain.

At a glance

Mechanism of action

As a nonsteroidal anti-inflammatory drug (NSAID), loxoprofen sodium blocks COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin levels, the drug provides analgesic, anti-inflammatory, and antipyretic effects. Loxoprofen is a prodrug that is metabolized in the body to its active form.

Approved indications

• Acute pain and inflammation
• Postoperative pain
• Rheumatoid arthritis
• Osteoarthritis

Common side effects

• Gastrointestinal upset (nausea, dyspepsia)
• Abdominal pain
• Headache
• Dizziness
• Rash

Key clinical trials

• Autologous Platelet Rich Plasma on Low Back Pain (NA)
• An in Vivo Bioequivalence Study of 2 Loxoprofen Sodium Products in Vietnamese Healthy Male Volunteers (PHASE1)
• Efficacy and Safety of Loxoprofen Hydrogel Patch in Patients With Ankylosing Spondylitis (PHASE4)
• Japanese IP-TN Trial (PHASE3)
• Comparative Study of Loxoprofen Sodium Transdermal Patch and Loxonin® Tablets for the Treatment of Acute Trauma (PHASE3)

Primary sources

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