{"id":"loxoprofen-sodium-tablet","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset (nausea, dyspepsia)"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Rash"}]},"_chembl":{"chemblId":"CHEMBL66552","moleculeType":"Small molecule","molecularWeight":"268.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a nonsteroidal anti-inflammatory drug (NSAID), loxoprofen sodium blocks COX-1 and COX-2 enzymes, which are responsible for producing prostaglandins that mediate inflammation, pain, and fever. By reducing prostaglandin levels, the drug provides analgesic, anti-inflammatory, and antipyretic effects. Loxoprofen is a prodrug that is metabolized in the body to its active form.","oneSentence":"Loxoprofen sodium inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:41:17.192Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain and inflammation"},{"name":"Postoperative pain"},{"name":"Rheumatoid arthritis"},{"name":"Osteoarthritis"}]},"trialDetails":[{"nctId":"NCT02983747","phase":"NA","title":"Autologous Platelet Rich Plasma on Low Back Pain","status":"UNKNOWN","sponsor":"Shanghai Changzheng Hospital","startDate":"2019-11-01","conditions":"Low Back Pain","enrollment":112},{"nctId":"NCT04386122","phase":"PHASE1","title":"An in Vivo Bioequivalence Study of 2 Loxoprofen Sodium Products in Vietnamese Healthy Male Volunteers","status":"COMPLETED","sponsor":"Centre of Clinical Pharmacology, Hanoi Medical University","startDate":"2020-05-07","conditions":"Bioequivalence","enrollment":24},{"nctId":"NCT03800797","phase":"PHASE4","title":"Efficacy and Safety of Loxoprofen Hydrogel Patch in Patients With Ankylosing Spondylitis","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2015-05-25","conditions":"Ankylosing Spondylitis","enrollment":70},{"nctId":"NCT02831569","phase":"PHASE3","title":"Japanese IP-TN Trial","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2016-07-27","conditions":"Pain","enrollment":80},{"nctId":"NCT02616068","phase":"PHASE3","title":"Comparative Study of Loxoprofen Sodium Transdermal Patch and Loxonin® Tablets for the Treatment of Acute Trauma","status":"COMPLETED","sponsor":"Daiichi Sankyo Brasil Farmacêutica LTDA","startDate":"2015-10","conditions":"Trauma, Pain","enrollment":242}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Loxoprofen tablet"],"phase":"marketed","status":"active","brandName":"Loxoprofen sodium tablet","genericName":"Loxoprofen sodium tablet","companyName":"Sun Yat-sen University","companyId":"sun-yat-sen-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Loxoprofen sodium inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation and pain. Used for Mild to moderate pain, Inflammation and fever, Postoperative pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}