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Lower Bupivacaine Concentration
Lower concentration bupivacaine reduces systemic toxicity while maintaining local anesthetic efficacy through decreased plasma levels of the active agent.
Lower concentration bupivacaine reduces systemic toxicity while maintaining local anesthetic efficacy through decreased plasma levels of the active agent. Used for Local and regional anesthesia with reduced systemic toxicity risk.
At a glance
| Generic name | Lower Bupivacaine Concentration |
|---|---|
| Sponsor | University of Chile |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that blocks sodium channels in nerve fibers. By formulating it at lower concentrations, the drug achieves therapeutic local anesthetic effects with reduced risk of central nervous system and cardiac toxicity that can occur with higher systemic exposure. This approach maintains clinical efficacy for regional anesthesia while improving the safety profile.
Approved indications
- Regional anesthesia and nerve blocks
- Local infiltration anesthesia
Common side effects
- Systemic toxicity (CNS effects)
- Cardiac arrhythmias
- Hypotension
- Local tissue irritation
Key clinical trials
- Clinical Observation of Bupivacaine Liposome for Lower Extremity Nerve Block (PHASE2)
- The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction Surgery (PHASE3)
- Drug Concentration and Volume on Adequate Labor Analgesia With PIEB (PHASE4)
- The Efficacy of Thoracoabdominal Nerve Block With Serratus Intercostal Plane and Rectus Sheath Block in Cholecystectomy (NA)
- Multimodal Analgesia Versus Peripheral Nerve Block for Postoperative Pain Management After Lower Limb Injury Surgery (NA)
- The Prolonging Effect of Dexmedetomidine on Spinal Anesthesia Through Different Routes if Administrations (PHASE4)
- Effect of Higher Volume and Lower Dose on Analgesic Quality During Labor Analgesia With Dural Puncture Epidural (NA)
- Comparison Between the Caudal Block and Other Methods of Postoperative Pain Relief in Children Undergoing Circumcision
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lower Bupivacaine Concentration CI brief — competitive landscape report
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- University of Chile portfolio CI