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This approach maintains clinical efficacy for regional anesthesia while improving the safety profile.","oneSentence":"Lower concentration bupivacaine reduces systemic toxicity while maintaining local anesthetic efficacy through decreased plasma levels of the active agent.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:53:27.863Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Regional anesthesia and nerve blocks"},{"name":"Local infiltration anesthesia"}]},"trialDetails":[{"nctId":"NCT07366905","phase":"PHASE2","title":"Clinical Observation of Bupivacaine Liposome for Lower Extremity Nerve Block","status":"NOT_YET_RECRUITING","sponsor":"Hainan Medical College","startDate":"2026-02","conditions":"Patients Eligible for Elective Lower Extremity Femoral Nerve Surgery, Knee Arthroscopic Surgery","enrollment":60},{"nctId":"NCT05171179","phase":"PHASE3","title":"The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction 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Used for Local and regional anesthesia with reduced systemic toxicity risk.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}