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Low-dose PRP
Low-dose PRP (platelet-rich plasma) delivers concentrated platelets and growth factors to damaged tissues to promote healing and reduce inflammation.
Low-dose PRP (platelet-rich plasma) delivers concentrated platelets and growth factors to damaged tissues to promote healing and reduce inflammation. Used for Osteoarthritis (knee, hip, shoulder), Tendinopathy and ligament injuries, Muscle injuries.
At a glance
| Generic name | Low-dose PRP |
|---|---|
| Sponsor | Hospital for Special Surgery, New York |
| Drug class | Autologous cell therapy / Regenerative medicine product |
| Modality | Biologic |
| Therapeutic area | Orthopedics / Regenerative Medicine |
| Phase | FDA-approved |
Mechanism of action
PRP is an autologous blood product prepared by centrifuging a patient's own blood to concentrate platelets, which contain growth factors (PDGF, VEGF, FGF, TGF-β) and cytokines. When injected into injured or degenerative tissues, these factors stimulate angiogenesis, cell proliferation, and tissue remodeling. The low-dose formulation aims to optimize therapeutic benefit while minimizing volume and cost.
Approved indications
- Osteoarthritis (knee, shoulder, hip)
- Tendinopathy and ligament injuries
- Muscle strains
Common side effects
- Injection site pain or swelling
- Temporary increase in symptoms
- Infection (rare)
Key clinical trials
- PRP for Glenohumeral Osteoarthritis (PHASE4)
- Intra-discal Injection of PRP for Low Back Pain (NA)
- Influence of PRGF (Plasma Rich in Growth Factors) Puncture in Ovaries With Low Follicular Reservetechniques (PHASE3)
- A Study of BI 765128 in Patients With an Eye Condition Called Diabetic Macular Ischemia Who Have Received Laser Treatment (PHASE1, PHASE2)
- Assessment of Different Clinical Techniques to Treat Patients With Chronic Low Back Pain (NA)
- Knee Osteoarthritis and Rehabilitation (NA)
- HORNBILL: A Study to Test Different Doses of BI 764524 in Patients Who Have Had Laser Treatment for a Type of Diabetic Eye Disease Called Diabetic Retinopathy With Diabetic Macular Ischemia (PHASE1, PHASE2)
- Efficacy of Intra-articular Injection of Human Amniotic Suspension Allograft and Platelet-rich Plasma in the Treatment of Knee Osteoarthritis. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Low-dose PRP CI brief — competitive landscape report
- Low-dose PRP updates RSS · CI watch RSS
- Hospital for Special Surgery, New York portfolio CI