{"id":"low-dose-prp","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or swelling"},{"rate":null,"effect":"Temporary increase in symptoms"},{"rate":null,"effect":"Infection (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PRP is an autologous blood product prepared by centrifuging a patient's own blood to concentrate platelets, which contain growth factors (PDGF, VEGF, FGF, TGF-β) and cytokines. When injected into injured or degenerative tissues, these factors stimulate angiogenesis, cell proliferation, and tissue remodeling. The low-dose formulation aims to optimize therapeutic benefit while minimizing volume and cost.","oneSentence":"Low-dose PRP (platelet-rich plasma) delivers concentrated platelets and growth factors to damaged tissues to promote healing and reduce inflammation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:53:27.253Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis (knee, shoulder, hip)"},{"name":"Tendinopathy and ligament injuries"},{"name":"Muscle strains"}]},"trialDetails":[{"nctId":"NCT05675527","phase":"PHASE4","title":"PRP for Glenohumeral Osteoarthritis","status":"RECRUITING","sponsor":"Hospital for Special Surgery, New York","startDate":"2023-05-02","conditions":"Shoulder Osteoarthritis","enrollment":135},{"nctId":"NCT03712527","phase":"NA","title":"Intra-discal Injection of PRP for Low Back Pain","status":"ACTIVE_NOT_RECRUITING","sponsor":"University Hospital, Montpellier","startDate":"2018-11-15","conditions":"Chronic Low Back Pain","enrollment":126},{"nctId":"NCT02992756","phase":"PHASE3","title":"Influence of PRGF (Plasma Rich in Growth Factors) Puncture in Ovaries With Low Follicular Reservetechniques","status":"TERMINATED","sponsor":"IVI Bilbao","startDate":"2021-06-29","conditions":"Low Ovarian Reserve","enrollment":51},{"nctId":"NCT04919499","phase":"PHASE1, PHASE2","title":"A Study of BI 765128 in Patients With an Eye Condition Called Diabetic Macular Ischemia Who Have Received Laser Treatment","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2021-07-30","conditions":"Diabetic Retinopathy","enrollment":46},{"nctId":"NCT06453291","phase":"NA","title":"Assessment of Different Clinical Techniques to Treat Patients With Chronic Low Back Pain","status":"RECRUITING","sponsor":"Iffat Anwar Medical Complex","startDate":"2024-07-10","conditions":"Chronic Low Back Pain (CLBP)","enrollment":100},{"nctId":"NCT06432842","phase":"NA","title":"Knee Osteoarthritis and Rehabilitation","status":"RECRUITING","sponsor":"Karabuk University","startDate":"2023-07-01","conditions":"Knee Osteoarthritis","enrollment":30},{"nctId":"NCT04424290","phase":"PHASE1, PHASE2","title":"HORNBILL: A Study to Test Different Doses of BI 764524 in Patients Who Have Had Laser Treatment for a Type of Diabetic Eye Disease Called Diabetic Retinopathy With Diabetic Macular Ischemia","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2020-06-12","conditions":"Diabetic Retinopathy","enrollment":45},{"nctId":"NCT04698265","phase":"NA","title":"Efficacy of Intra-articular Injection of Human Amniotic Suspension Allograft and Platelet-rich Plasma in the Treatment of Knee Osteoarthritis.","status":"UNKNOWN","sponsor":"Kaohsiung Veterans General Hospital.","startDate":"2021-01-01","conditions":"Knee Osteoarthristis","enrollment":150},{"nctId":"NCT04242719","phase":"NA","title":"Management of Deep Retinal Capillary Ischemia by Electromagnetic Stimulation and Platelet- Rich Plasma","status":"COMPLETED","sponsor":"Ankara Universitesi Teknokent","startDate":"2018-01-01","conditions":"Deep Retinal Capillary Ischemia, Paracentral Acute Middle Maculopathy, Acute Macular Neuroretinopathy","enrollment":28},{"nctId":"NCT00473668","phase":"PHASE3","title":"Non-inferiority of GSK Biologicals' DTPw-HBV/Hib Compared to Two Formulations of GSK Biologicals' DTPw-HBV/Hib","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-06-01","conditions":"Whole Cell Pertussis, Haemophilus Influenzae Type b, Tetanus","enrollment":300},{"nctId":"NCT01061541","phase":"PHASE2","title":"Immunogenicity, Safety & Reactogenicity of GSK Vaccine Tritanrix™-HepB/Hib2.5 Compared to GSK Vaccine Tritanrix™-HepB/Hiberix™","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2003-08","conditions":"Haemophilus Influenzae Type b","enrollment":192}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":82,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Low-dose PRP","genericName":"Low-dose PRP","companyName":"Hospital for Special Surgery, New York","companyId":"hospital-for-special-surgery-new-york","modality":"Biologic","firstApprovalDate":"","aiSummary":"Low-dose PRP (platelet-rich plasma) delivers concentrated platelets and growth factors to damaged tissues to promote healing and reduce inflammation. Used for Osteoarthritis (knee, hip, shoulder), Tendinopathy and ligament injuries, Muscle injuries.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}