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Low-dose Clomiphene
Low-dose Clomiphene is a Selective estrogen receptor modulator (SERM) Small molecule drug developed by Weill Medical College of Cornell University. It is currently FDA-approved for Male hypogonadism / testosterone deficiency, Male infertility associated with low testosterone. Also known as: clomiphene citrate with low dose gonadotropins.
Low-dose clomiphene is a selective estrogen receptor modulator (SERM) that blocks negative feedback on the hypothalamic-pituitary-gonadal axis, stimulating endogenous testosterone production in men.
Low-dose Clomiphene is used to treat conditions such as Infertility, Secondary Hypogonadism, and Male Infertility, as indicated by ClinicalTrials.gov. It works as an estrogen receptor alpha modulator, a small molecule that interacts with the estrogen receptor, according to ChEMBL.
At a glance
| Generic name | Low-dose Clomiphene |
|---|---|
| Also known as | clomiphene citrate with low dose gonadotropins |
| Sponsor | Weill Medical College of Cornell University |
| Drug class | Selective estrogen receptor modulator (SERM) |
| Target | Estrogen receptor (ER-α and ER-β) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology |
| Phase | FDA-approved |
Mechanism of action
Clomiphene citrate acts as a partial antagonist at estrogen receptors in the hypothalamus and pituitary gland, preventing the normal inhibitory feedback of estrogen on gonadotropin-releasing hormone (GnRH) secretion. This leads to increased release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn stimulate the testes to produce testosterone. At low doses, this effect is optimized to increase testosterone while minimizing suppression of spermatogenesis.
Approved indications
- Male hypogonadism / testosterone deficiency
- Male infertility associated with low testosterone
Common side effects
- Visual disturbances (blurred vision, scotomata)
- Hot flashes
- Mood changes / irritability
- Headache
- Nausea
Key clinical trials
- Effectiveness of Low Dose Gonadotropin Stimulation Protocol Vs High Dose Gonadotropin Protocol in Poor Responders (EARLY_PHASE1)
- Use of Low Dose of HCG During Ovulation Induction With CC in Women With CC Resistant PCOS (PHASE4)
- HRT Versus MOS for Endometrial Preparation Prior to FET in Non PCOS Patients (PHASE4)
- Acupuncture and Clomiphene Citrate on Live Birth in Anovulatory Women With Polycystic Ovary Syndrome (NA)
- LOD vs Gn in Anovulatory PCOs Resistant to First Line Agents (NA)
- Efficacy Study Comparing the Effect of Clomiphencitrate to an Antagonist Protocol (PHASE4)
- HRT Versus MOS for Endometrial Preparation Prior to FET in PCOS Patients
- Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Low-dose Clomiphene CI brief — competitive landscape report
- Low-dose Clomiphene updates RSS · CI watch RSS
- Weill Medical College of Cornell University portfolio CI
Frequently asked questions about Low-dose Clomiphene
What is Low-dose Clomiphene?
How does Low-dose Clomiphene work?
What is Low-dose Clomiphene used for?
Who makes Low-dose Clomiphene?
Is Low-dose Clomiphene also known as anything else?
What drug class is Low-dose Clomiphene in?
What development phase is Low-dose Clomiphene in?
What are the side effects of Low-dose Clomiphene?
What does Low-dose Clomiphene target?
Related
- Drug class: All Selective estrogen receptor modulator (SERM) drugs
- Target: All drugs targeting Estrogen receptor (ER-α and ER-β)
- Manufacturer: Weill Medical College of Cornell University — full pipeline
- Therapeutic area: All drugs in Endocrinology
- Indication: Drugs for Male hypogonadism / testosterone deficiency
- Indication: Drugs for Male infertility associated with low testosterone
- Also known as: clomiphene citrate with low dose gonadotropins
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing