{"id":"low-dose-clomiphene","safety":{"commonSideEffects":[{"rate":null,"effect":"Visual disturbances (blurred vision, scotomata)"},{"rate":null,"effect":"Hot flashes"},{"rate":null,"effect":"Mood changes / irritability"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL3185958","moleculeType":"Small molecule","molecularWeight":"598.09"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clomiphene citrate acts as a partial antagonist at estrogen receptors in the hypothalamus and pituitary gland, preventing the normal inhibitory feedback of estrogen on gonadotropin-releasing hormone (GnRH) secretion. This leads to increased release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn stimulate the testes to produce testosterone. At low doses, this effect is optimized to increase testosterone while minimizing suppression of spermatogenesis.","oneSentence":"Low-dose clomiphene is a selective estrogen receptor modulator (SERM) that blocks negative feedback on the hypothalamic-pituitary-gonadal axis, stimulating endogenous testosterone production in men.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:53:15.618Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Male hypogonadism / testosterone deficiency"},{"name":"Male infertility associated with low testosterone"}]},"trialDetails":[{"nctId":"NCT06778733","phase":"EARLY_PHASE1","title":"Effectiveness of Low Dose Gonadotropin Stimulation Protocol Vs High Dose Gonadotropin Protocol in Poor Responders","status":"COMPLETED","sponsor":"University of Athens","startDate":"2022-01-01","conditions":"Female Infertility","enrollment":22},{"nctId":"NCT02436226","phase":"PHASE4","title":"Use of Low Dose of HCG During Ovulation Induction With CC in Women With CC Resistant PCOS","status":"COMPLETED","sponsor":"Mohamed Sayed Abdelhafez","startDate":"2016-03","conditions":"Infertility, Polycystic Ovarian Syndrome","enrollment":300},{"nctId":"NCT02330757","phase":"PHASE4","title":"HRT Versus MOS for Endometrial Preparation Prior to FET in Non PCOS Patients","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2016-10-10","conditions":"Infertility","enrollment":150},{"nctId":"NCT01573858","phase":"NA","title":"Acupuncture and Clomiphene Citrate on Live Birth in Anovulatory Women With Polycystic Ovary Syndrome","status":"COMPLETED","sponsor":"Heilongjiang University of Chinese Medicine","startDate":"2012-07-06","conditions":"Pregnancy, Polycystic Ovary Syndrome, Infertility","enrollment":1000},{"nctId":"NCT04325295","phase":"NA","title":"LOD vs Gn in Anovulatory PCOs Resistant to First Line Agents","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2020-12","conditions":"Polycystic Ovary 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Infertility","enrollment":13},{"nctId":"NCT02458963","phase":"PHASE4","title":"IVF Versus Gonadotropin Therapy in Women With CC Resistant PCOS","status":"WITHDRAWN","sponsor":"Mohamed Sayed Abdelhafez","startDate":"2016-01","conditions":"Infertility, Polycystic Ovarian Syndrome","enrollment":""},{"nctId":"NCT01577199","phase":"PHASE4","title":"RCT of Low-dose Clomiphene vs. High Dose Gonadotropin Protocol for IVF Poor Responders","status":"WITHDRAWN","sponsor":"Weill Medical College of Cornell University","startDate":"2012-04","conditions":"Infertility","enrollment":""},{"nctId":"NCT02288143","phase":"PHASE4","title":"COmbining Oral Letrozole and Clomiphene for Ovarian Stimulation","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2015-01","conditions":"Infertility","enrollment":28},{"nctId":"NCT01386606","phase":"PHASE2","title":"The Effect on Androxal Versus Androgel on Morning Testosterone in Men With Secondary Hypogonadism (Low Testosterone)","status":"COMPLETED","sponsor":"Repros Therapeutics Inc.","startDate":"2011-06","conditions":"Secondary Hypogonadism","enrollment":60},{"nctId":"NCT00796289","phase":"PHASE2","title":"Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH Delivered From a Iontophoretic Patch Compared to Oral Treatment With Clomiphene or Placebo in Infertile Females","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2009-02","conditions":"Infertility","enrollment":350},{"nctId":"NCT01923194","phase":"PHASE3","title":"Evaluation of Efficacy and Safety of Highly Purified Urofollitropin for Ovulation Induction in Chinese Females","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2013-10","conditions":"Anovulation","enrollment":215},{"nctId":"NCT01212263","phase":"NA","title":"Clomiphene Citrate (CC) Co-treatment With HP Urinary FSH vs HP Urinary FSH in CC-resistant PCOS","status":"COMPLETED","sponsor":"Mansoura Integrated Fertility Center","startDate":"2010-01","conditions":"Polycystic Ovary Syndrome","enrollment":174},{"nctId":"NCT01340521","phase":"PHASE1, PHASE2","title":"Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) Response to Low Dose Clomiphene Citrate in Normally Menstruating Fertile Women","status":"COMPLETED","sponsor":"Milton S. Hershey Medical Center","startDate":"1991-03","conditions":"Infertility","enrollment":25},{"nctId":"NCT00947713","phase":"PHASE1, PHASE2","title":"Comparison of Micro-dose Human Chorionic Gonadotropin (hCG) With Human Menopausal Gonadotropin (HMG) in Polycystic Ovary Syndrome","status":"COMPLETED","sponsor":"Royan Institute","startDate":"2009-08","conditions":"Endocrine System Diseases, Gonadal Disorders","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":17,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["clomiphene citrate with low dose gonadotropins"],"phase":"marketed","status":"active","brandName":"Low-dose Clomiphene","genericName":"Low-dose Clomiphene","companyName":"Weill Medical College of Cornell University","companyId":"weill-medical-college-of-cornell-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Low-dose Clomiphene is used to treat conditions such as Infertility, Secondary Hypogonadism, and Male Infertility, as indicated by ClinicalTrials.gov. It works as an estrogen receptor alpha modulator, a small molecule that interacts with the estrogen receptor, according to ChEMBL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}